High levels of factor IX increase the risk of venous thrombosis.
High levels of factor IX increase the risk of venous thrombosis.
复制标题
高水平的因子 IX 会增加静脉血栓形成的风险。
作者：
A. Vlieg;Irma K. van der Linden;R. Bertina;F. Rosendaal
凝血因子VIII的血浆水平升高（> 150 IU/dL）是深静脉血栓形成（DVT）的重要危险因素。因子VIII是因子IXa在因子X活化中的辅因子。凝血因子IX水平升高的个体发生血栓形成的风险尚不清楚。本研究探讨了因子IX水平升高在DVT发展中的作用。我们比较了426例首次客观诊断为DVT的患者和473例对照人群。本研究是一项关于静脉血栓形成风险因素的大型人群病例对照研究的一部分，莱顿血栓形成研究（LETS）。使用在对照受试者中测量的第90百分位数（P（90）= 129 U/dL）作为因子IX水平的截止点，我们发现与因子IX水平低于该截止点的个体相比，因子IX水平高于129 U/dL的个体的风险增加2至3倍。调整可能的混杂因素（年龄、性别、口服避孕药使用和高水平的因子VIII、XI和维生素K依赖性蛋白）后，该风险不受影响。排除已知遗传性疾病的个体后，我们仍然发现比值比（OR）为2.5（95%置信区间[CI]：1.6-3.9）。女性（OR：2.6，CI：1.6-4.3）高于男性（OR：1.9，CI：1.0-3.6），未使用口服避孕药的绝经前妇女组的风险最高（OR：12.4，CI：3.3-47.2）。这些结果表明，因子IX水平升高是DVT的常见危险因素。（血。2000;95：3678-3682）
Elevated plasma levels of factor VIII (> 150 IU/dL) are an important risk factor for deep vein thrombosis (DVT). Factor VIII is the cofactor of factor IXa in the activation of factor X. The risk of thrombosis in individuals with an elevated factor IX level is unknown. This study investigated the role of elevated factor IX levels in the development of DVT. We compared 426 patients with a first objectively diagnosed episode of DVT with 473 population controls. This study was part of a large population-based case-control study on risk factors for venous thrombosis, the Leiden Thrombophilia Study (LETS). Using the 90th percentile measured in control subjects (P(90) = 129 U/dL) as a cutoff point for factor IX levels, we found a 2- to 3-fold increased risk for individuals who have factor IX levels above 129 U/dL compared with individuals having factor IX levels below this cutoff point. This risk was not affected by adjustment for possible confounders (age, sex, oral contraceptive use, and high levels of factor VIII, XI, and vitamin K-dependent proteins). After exclusion of individuals with known genetic disorders, we still found an odds ratio (OR) of 2.5 (95% confidence interval [CI]: 1.6-3.9). The risk was higher in women (OR: 2.6, CI: 1.6-4.3) than in men (OR: 1.9, CI: 1.0-3.6) and appeared highest in the group of premenopausal women not using oral contraceptives (OR: 12.4, CI: 3.3-47.2). These results show that an elevated level of factor IX is a common risk factor for DVT. (Blood. 2000;95:3678-3682)
影响因子：
15.9
作者：
COMP, PC;NIXON, RR;ESMON, CT
通讯作者：
ESMON, CT