Inflammatory Cytokines and Sleep Disturbance in Patients with Temporomandibular Disorders
Inflammatory Cytokines and Sleep Disturbance in Patients with Temporomandibular Disorders
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DOI：
10.11607/ofph.1367
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发表时间：
2016-01-01
影响因子：
2.5
通讯作者：
Chung, Jin Woo
中科院分区：
文献类型：
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作者：
Park, Ji Woon;Chung, Jin Woo
目的：探讨颞下颌关节紊乱病（TMD）疼痛患者睡眠障碍的程度及其与血浆细胞因子水平的关系。方法：40例女性TMD患者和20例年龄、性别和体重指数（BMI）相匹配的健康受试者入选。使用TMD研究诊断标准诊断TMD。根据慢性疼痛分级量表的结果，将TMD患者分为低或高残疾。采用匹兹堡睡眠质量指数（PSQI）和埃普沃思嗜睡量表（ESS）评定睡眠质量。从上午9点至中午采集的血样中测定白细胞介素（IL）-1 β、IL-6、IL-10、肿瘤坏死因子-α（TNF-α）和C-反应蛋白（CRP）的血浆浓度。统计分析包括Kruskal-Wallis和单因素方差分析检验，以比较不同组之间的结果，以及多变量一般线性模型，以评估睡眠状态对细胞因子水平的影响。结果：重度残疾组PSQI和ESS评分最高（P
Aims: To assess the degree and interrelationship of sleep disturbance and plasma cytokine levels in temporomandibular disorder (TMD) pain patients. Methods: Forty female TMD patients and 20 age-, sex-, and body mass index (BMI)-matched healthy subjects were enrolled. TMD was diagnosed using the Research Diagnostic Criteria for TMD. The TMD patients were classified as having low or high disability according to Graded Chronic Pain Scale findings. The Pittsburgh Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS) were used to measure sleep quality. Plasma concentrations of interleukin (IL)-1 beta, IL-6, IL-10, tumor necrosis factor-alpha (TNF-alpha), and C-reactive protein (CRP) were measured from blood samples collected between 9 am and noon. Statistical analyses included Kruskal-Wallis and one-way analysis of variance tests to compare results between different groups and multivariate general linear models to evaluate the effect of sleep status on cytokine levels. Results: The high-disability group had the highest PSQI and ESS scores (P