Anatomically Based Analysis of Radioaerosol Distribution in Pulmonary Scintigraphy: A Feasibility Study in Asthmatics.
Anatomically Based Analysis of Radioaerosol Distribution in Pulmonary Scintigraphy: A Feasibility Study in Asthmatics.
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肺闪烁扫描中放射性气溶胶分布的解剖学分析：哮喘的可行性研究。
DOI：
10.1089/jamp.2017.1403
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发表时间：
2018
影响因子：
3.4
通讯作者：
Venegas,JoseG
中科院分区：
文献类型：
--
作者：
Alcoforado,Luciana;DornelasdeAndrade,Armèle;Herraiz,JoaquinL;Brandão,SimoneCristinaSoares;Barcelar,JacquelinedeMelo;Fink,JamesB;Venegas,JoseG
人工分析二维（2D）闪烁图来评估气溶胶沉积通常是主观的，并且在量化中央和远端气道区域差异方面的敏感性降低。目的：(1)提出一种基于三维（3D）解剖一致感兴趣区域（roi）的二维扫描分析方法；(2)评估16例中重度哮喘患者外周血周/中枢计数比（P/C2D）和穿透指数（pi）；(3)比较该方法与手动跟踪roi的方法的再现性。方法：使用定制软件对二维扫描进行分析，该软件缩放到二维投影的三维解剖特征上，这些特征来自人口平均计算机断层扫描（CT）胸部扫描。通过计算机和人工跟踪标准矩形盒定义了矩形盒ROI （bROI）和解剖形ROI (aROI) （manual ROI [mROI]）。这些roi被定义为每次扫描的五次非连续时间，并估计p / c2d的平均值和变异性。根据肺和气道的CT估计，bROI和aROI下的体积，2D穿透指数（PI2D）和3D穿透指数（PI3D）分别定义为中央和周围ROIs以及中央和远端气道中气溶胶沉积的体积归一化比率。结果：P/ c2d值及其变异性受到roi的形状和定义方法的影响：与bROI相比，mROI的P/ c2d值系统地更大，变量更多（P < 0.005）。aROI的p / c2d高于bROI，变异性低于bROI （p< 0.001）。对于aROI和bROI， pi2d平均相同，并且显著（~ 30倍）大于pi3d （p< 0.001）。通过我们的分析获得的BothPI2DandPI3D与两次扫描（沉积和体积）获得的文献值比较良好。结论：我们的研究结果表明，二维扫描成像可以利用三维CT数据的解剖学基础roi进行分析，从而客观且增强了再现性值，描述了气管支气管树中放射性气溶胶沉积的分布模式。
Introduction:Manual analysis of two-dimensional (2D) scintigraphy to evaluate aerosol deposition is usually subjective and has reduced sensitivity to quantify regional differences between central and distal airways.Aims:(1) To present a method to analyze 2D scans based on three-dimensional (3D)-linked anatomically consistent regions of interest (ROIs); (2) to evaluate peripheral-to-central counts ratio (P/C2D) and penetration indices (PIs) for a set of 16 subjects with moderate-to-severe asthma; and (3) to compare the reproducibility of this method against one with manually traced ROIs.Methods:Two-dimensional scans were analyzed using custom software that scaled onto 2D-projections' 3D anatomical features, obtained from population-averaged computed tomography (CT) chest scans. ROIs for a rectangular box (bROI) and an anatomically shaped ROI (aROI) were defined by computer and by manually tracing the standard rectangular box (manual ROI [mROI]). These ROIs were defined five nonconsecutive times for each scan and average value and variability of theP/C2Dwere estimated. Based on CT estimates of lung and airways, volumes lying under the bROI and aROI, a 2D penetration index (PI2D) and a 3D penetration index (PI3D), were defined as volume-normalized ratios of aerosol deposition in central and peripheral ROIs and in central and distal airways, respectively.Results:P/C2Dvalues and their variability, were influenced by the shape and method to define the ROIs: TheP/C2Dwas systematically greater and more variable for mROI versus bROI (p< 0.005). TheP/C2Dfor aROI was higher and its variability lower than those for the bROI (p< 0.001). ThePI2Dwas in average the same for aROI and bROI, and is substantially (∼30 × ) greater thanPI3D(p< 0.001). BothPI2DandPI3D, obtained with our analysis, compared well with literature values obtained with two scans (deposition and volume).Conclusion:Our results demonstrate that 2D scintigraphy can be analyzed using anatomically based ROIs from 3D CT data, allowing objective and enhanced reproducibility values describing the distribution pattern of radioaerosol deposition in the tracheobronchial tree.