Bioconcentration and disposition of 1,3,6,8-tetrachlorodibenzo-p-dioxin and octachlorodibenzo-p-dioxin by rainbow trout and fathead minnows
Bioconcentration and disposition of 1,3,6,8-tetrachlorodibenzo-p-dioxin and octachlorodibenzo-p-dioxin by rainbow trout and fathead minnows
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虹鳟鱼和黑头鱼对 1,3,6,8-四氯二苯并-对-二恶英和八氯二苯-对-二恶英的生物富集和处置
DOI：
10.1002/etc.5620050305
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发表时间：
1986
影响因子：
4.1
通讯作者：
G. Webster
中科院分区：
文献类型：
--
作者：
D. Muir;A. Yarechewski;A. Knoll;G. Webster
采用5 d的吸收期和24 ~ 48 d的净化期，研究了14 C标记的1，3，6，8-四氯二苯并二恶英（TCDD）和八氯二苯并二恶英（OCDD）在虹鳟鱼（萨尔莫）和黑头呆鱼（Pimephales promelas）体内的积累规律。1，3，6，8-四氯二苯并对二恶英的平均接触浓度范围为4至211纳克/升，而五氯二苯并对二恶英的平均接触浓度范围为9至415纳克/升。采用双室一级速率模型计算得出，1，3，6，8-四氯二苯并对二恶英在鳟鱼鱼苗和小鱼体内的平衡生物富集系数分别为2，100和5，702，而在同一物种体内，八氯二苯并对二恶英的平衡生物富集系数分别为85和2，226。两种异构体的消除速度都很快，1，3，6，8-四氯二苯并对二恶英的14 C半衰期为6至9天，而八氯二苯并对二恶英的半衰期为5至13天。胆汁中1，3，6，8-TCDD和OCDD的浓度最高。1，3，6，8-TCDD在胆汁中的代谢产物被鉴定为羟基化四氯衍生物的结合物。虹鳟鱼的饮食暴露导致低积累系数，从0.034的OCDD到0.018的1，3，6，8-TCDD，基于甲苯可提取的放射性。
Accumulation of 14C-labeled 1,3,6,8-tetrachlorodibenzo-p-dioxin (TCDD) and octachlorodibenzo-p-dioxin (OCDD) from water by rainbow trout fry (Salmo gairdneri) and fathead minnows (Pimephales promelas) was studied using a 5-d uptake and 24 to 48-d depuration period. Average exposure concentrations ranged from 4 to 211 ng/L for 1,3,6,8-TCDD and from 9 to 415 ng/L for OCDD. Equilibrium bioconcentration factors for total 14C in fish, calculated by use of a two-compartment first-order rate model, were 2,100 and 5,702 for 1,3,6,8-TCDD in trout fry and minnows, respectively, and 85 and 2,226 for OCDD in the same species. Elimination rates of both isomers were rapid, with half-lives of 14C ranging from 6 to 9 d for 1,3,6,8-TCDD and from 5 to 13 d for OCDD. The highest concentrations of radiolabeled 1,3,6,8-TCDD and OCDD were found in bile. A metabolite of 1,3,6,8-TCDD in bile was identified as a conjugate of a hydroxylated tetrachloro-derivative. Dietary exposure of rainbow trout resulted in low accumulation factors, ranging from 0.034 for OCDD to 0.018 for 1,3,6,8-TCDD, based on toluene-extractable radioactivity.