Dietary patterns and survival of older Europeans:: The EPIC-Elderly study (European Prospective Investigation into Cancer and Nutrition)
Dietary patterns and survival of older Europeans:: The EPIC-Elderly study (European Prospective Investigation into Cancer and Nutrition)
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DOI：
10.1017/s1368980007382487
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发表时间：
2007-06-01
影响因子：
3.2
通讯作者：
Trichopoulou, Antonia
中科院分区：
文献类型：
--
作者：
Bamia, Christina;Trichopoulos, Dimitrios;Trichopoulou, Antonia
目的：研究欧洲老年人的后天饮食模式与总体生存率之间的关系。设计和背景：这是一项多中心队列研究。在欧洲癌症与营养前瞻性调查（EPIC-Elderly队列）招募的60岁及以上受试者中，采用Cox回归分析调查流行的、后源性的植物性饮食模式与全因死亡率之间的关系。分析控制了所有已知的潜在危险因素。受试者：共有74 607名男性和女性，入组时年龄在60岁或以上，既往无冠心病、中风或癌症，有完整的饮食摄入信息和潜在的混杂变量，且截至2003年12月已知生存状态。结果：衡量坚持植物性饮食的评分的增加与较低的总体死亡率相关，一个标准差的增加对应于统计上显著降低14%（95%置信区间为5-23%）。在针对具体国家的分析中，这种明显的关联在希腊、西班牙、丹麦和荷兰更为明显，而在英国和德国则不存在。结论：在这些欧洲老年人中，更严格地坚持植物性饮食与较低的全因死亡率有关。该饮食评分与改良地中海饮食评分（Modified Mediterranean Diet score）呈中度正相关，改良地中海饮食评分已被先验构建，也被证明有利于同一epic -老年队列的生存。
Objective: To investigate the association of a posteriori dietary patterns with overall survival of older Europeans.Design and setting: This is a multi-centre cohort study. Cox regression analysis was used to investigate the association of the prevailing, a posteriori-derived, plant-based dietary pattern with all-cause mortality in a population of subjects who were 60 years or older at recruitment to the European Prospective Investigation into Cancer and Nutrition (EPIC-Elderly cohort). Analyses controlled for all known potential risk factors.Subjects: in total, 74 607 men and women, 60 years or older at enrolment and without previous coronary heart disease, stroke or cancer, with complete information about dietary intakes and potentially confounding variables, and with known survival status as of December 2003, were included in the analysis.Results: An increase in the score which measures the adherence to the plant-based diet was associated with a lower overall mortality, a one standard deviation increment corresponding to a statistically significant reduction of 14% (95% confidence interval 5-23%). In country-specific analyses the apparent association was stronger in Greece, Spain, Denmark and The Netherlands, and absent in the UK and Germany.Conclusions: Greater adherence to the plant-based diet that was defined a posteriori in this population of European elders is associated with lower all-cause mortality. This dietary score is moderately positively correlated with the Modified Mediterranean Diet Score that has been constructed a priori and was also shown to be beneficial for the Survival of the same EPIC-Elderly cohort.