Enhanced accumulation of injected inorganic mercury in renal outer medulla after unilateral nephrectomy.
Enhanced accumulation of injected inorganic mercury in renal outer medulla after unilateral nephrectomy.
复制标题
单侧肾切除术后肾外髓质注射无机汞的积累增加。
DOI：
10.1016/0041-008x(87)90043-3
复制
发表时间：
1987
影响因子：
3.8
通讯作者：
Diamond,GL
中科院分区：
文献类型：
--
作者：
Zalups,RK;Klotzbach,JM;Diamond,GL
本文观察了单侧肾切除对大鼠腹腔注射氯化汞（HgCl_2，0.5 μmol Hg/kg体重）后汞在肾内蓄积和分布的影响。在肾切除术后立即或10，28，或43天后注射氯化汞的大鼠，汞在肾外髓质的积累显着大于各自的假手术对照组大鼠。在注射HgCl 2后24小时，肾外髓质中汞的蓄积明显增加，并持续至少72小时。这种效应似乎是一种与肾外髓质特异相关的现象，即在肾皮质、内髓质、肝脏、血液或全身汞含量。尿汞排泄不受肾切除术的影响。因此，与单侧肾切除术相关的是全身给予无机汞的肾蓄积和肾内分布的变化，这些变化在肾脏代偿性生长的快速阶段（0-7天）完成后持续很长时间。
The effects of unilateral nephrectomy on renal accumulation and intrarenal distribution of mercury following a single injection of mercuric chloride (HgCl2, 0.5 μmol Hg/kg body wt, ip) were evaluated in the rat. In rats injected with HgCl2immediately after nephrectomy or 10, 28, or 43 days after nephrectomy, the accumulation of mercury in the renal outer medulla was significantly greater than in respective sham-operated control rats. The increased accumulation of mercury in renal outer medulla was evident at 24 hr after injection of HgCl2and persisted for at least 72 hr. The effect appeared to be a phenomenon associated specifically with the renal outer medulla in that elevated concentrations of mercury in the outer medulla were observed in the absence of similar elevations in the renal cortex, inner medulla, liver, and blood or in the whole body mercury content. Urinary excretion of mercury was unaffected by nephrectomy. Thus, associated with unilateral nephrectomy are changes in the renal accumulation and intrarenal distribution of systemically administered inorganic mercury that persist long after the rapid phase of compensatory renal growth (0–7 days) is completed.