Brocazines A-F, Cytotoxic Bisthiodiketopiperazine Derivatives from Penicillium brocae MA-231, an Endophytic Fungus Derived from the Marine Mangrove Plant Avicennia marina
Brocazines A-F, Cytotoxic Bisthiodiketopiperazine Derivatives from Penicillium brocae MA-231, an Endophytic Fungus Derived from the Marine Mangrove Plant Avicennia marina
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Brocazines A-F，细胞毒性双硫二酮哌嗪衍生物，来自青霉 MA-231，一种源自海洋红树林植物白骨壤的内生真菌
DOI：
10.1021/np500382k
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发表时间：
2014-08-01
影响因子：
5.1
通讯作者：
Wang, Bin-Gui
中科院分区：
文献类型：
--
作者：
Meng, Ling-Hong;Li, Xiao-Ming;Wang, Bin-Gui
从布鲁青霉MA-231的细胞毒提取物中分离和鉴定了6个新的二硫桥联二酮并哌嗪类化合物，溴代苯并[1-F](1-6)和一个已知的类似物(7)。通过对核磁共振和质谱学数据的详细解释，确定了这些化合物的结构。X-射线晶体分析确认了化合物1的结构，确定了化合物5的结构和绝对构型，而化合物1、4和6的绝对构型是通过与化合物1、2、5和6的CD数据进行比较而推断出来的。化合物1、2、5和6对几种肿瘤细胞具有细胞毒活性。
Six new disulfide-bridged diketopiperazine derivatives, brocazines A-F (1-6), along with one known analogue (7), were isolated and identified from the cytotoxic extract of Penicillium brocae MA-231, a fungus obtained from the fresh tissue of the marine mangrove plant Avicennia marina. The structures of these compounds were established on the basis of detailed interpretation of NMR and mass spectroscopic data. X-ray crystallographic analysis confirmed the structure of 1 and established the structure and absolute configuration of 5, while the absolute configurations for compounds 1, 4, and 6 were deduced by comparison of the CD data with those of S. Compounds 1, 2, 5, and 6 showed cytotoxic activities against several tumor cell lines.