New insights into the endocrine disrupting effects of brominated flame retardants
New insights into the endocrine disrupting effects of brominated flame retardants
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DOI：
10.1016/j.chemosphere.2008.04.081
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发表时间：
2008-09-01
期刊：
影响因子：
8.8
通讯作者：
Legler, Juliette
中科院分区：
文献类型：
--
作者：
Legler, Juliette
本文综述了溴化阻燃剂（BFR）的内分泌干扰（艾德）效应，并重点介绍了2007年4月在阿姆斯特丹举行的国际BFR研讨会上提出的有趣数据。以2002年撰写的评论为起点，审查了自2003年以来出版的约60份出版物。在哺乳动物和非哺乳动物模型中，BFR对甲状腺激素、雌激素和雄激素途径的体内影响有了新的认识，并强调了艾德效应的潜在机制的新（体外）发现。还特别注意了关于在相对较低的溴化阻燃剂浓度下的神经毒理学影响的报告，尽管与内分泌有关的机制存在争议。已发表的令人信服的证据表明，溴化阻燃剂，重要的是溴化阻燃剂代谢物，有可能在多个目标部位破坏内分泌系统。虽然一些研究表明啮齿动物模型中的效应浓度与人类和环境中遇到的水平之间存在较宽的安全范围，但其他研究表明，在发育的关键时间点暴露于与人类和野生动物相关的低Closes可能会对内分泌途径和（神经）发育产生深远影响。(c)2008爱思唯尔有限公司保留所有权利。
The Objective Of this review is to provide all overview of recent Studies demonstrating the endocrine disrupting (ED) effects of brominated flame retardants (BFRs), while highlighting interesting data presented at the recent international BFR workshop in Amsterdam in April, 2007. A review written in 2002 was used as a starting point and about 60 Publications published since 2003 were reviewed. New insights into the in vivo effects of BFRs on thyroid hormone, estrogen and androgen pathways in both mammalian and non-mammalian models are provided, and novel (in vitro) findings oil the mechanisms underlying ED effects are highlighted. Special attention is also given to reports on neurotoxicological effects at relatively low closes of BFRs, although an endocrine-related mechanism is disputable. Convincing evidence has been published showing that BFRs and importantly, BFR metabolites, have the potential to disrupt endocrine systems at multiple target sites. While some studies suggest a wide margin of safety between effect concentrations in rodent models and levels encountered in humans and the environment, other Studies demonstrate that exposure to low Closes relevant for humans and wildlife at critical time points in development can result in profound effects oil both endocrine pathways and (neuro)development. (c) 2008 Elsevier Ltd. All rights reserved.