Spike timing of dendrite-targeting bistratified cells during hippocampal network oscillations in vivo
Spike timing of dendrite-targeting bistratified cells during hippocampal network oscillations in vivo
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DOI：
10.1038/nn1159
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发表时间：
2004-01-01
影响因子：
25
通讯作者：
Somogyi, P
中科院分区：
文献类型：
--
作者：
Klausberger, T;Márton, LF;Somogyi, P
行为相关网络振荡在大脑皮层（包括海马体）中产生短暂的、功能连贯的神经元组装。在索马上和附近的抑制性输入被认为是锥体细胞的内在振荡和输出的相位，但是GABA释放到锥体细胞树突的功能仍然未知。我们记录了大鼠双层中间神经元的振荡锁定尖峰时间。这些细胞主要支配小树突状轴的锥体细胞共同对齐的mammatergic Schaffer侧支/连合输入。在theta振荡期间，双层细胞在平均而言锥体细胞树突最超极化的阶段激发。以躯体周围区为目标的中间神经元在早期阶段放电。在尖波相关的波纹，双复层细胞的放电频率高，与篮状细胞同相，平均1-2毫秒后，在锥体细胞胞体和树突的放电。我们的研究结果表明，bisteratively细胞有节奏地调节的神经元输入的树突的锥体细胞，积极促进精确的输入/输出转换在网络振荡。
Behavior-contingent network oscillations bring about transient, functionally coherent neuronal assemblies in the cerebral cortex, including the hippocampus. Inhibitory input on and close to the soma is believed to phase intrinsic oscillations and output of pyramidal cells, but the function of GABA release to pyramidal cell dendrites remains unknown. We recorded the oscillation-locked spike timing of identified bistratified interneurons in rats. These cells mainly innervated small dendritic shafts of pyramidal cells co-aligned with the glutamatergic Schaffer collateral/commissural input. During theta oscillations, bistratified cells fired at a phase when, on average, pyramidal cell dendrites are most hyperpolarized. Interneurons targeting the perisomatic domain discharge at an earlier phase. During sharp wave-associated ripples, bistratified cells fired with high frequency and in-phase with basket cells, on average 1-2 ms after the discharges in pyramidal cell somata and dendrites. Our results indicate that bistratified cells rhythmically modulate glutamatergic input to the dendrites of pyramidal cells to actively promote the precise input/output transformation during network oscillations.