Catalytic Dienylation: An Emergent Strategy for the Stereoselective Construction of Conjugated Dienes and Polyenes.
Catalytic Dienylation: An Emergent Strategy for the Stereoselective Construction of Conjugated Dienes and Polyenes.
复制标题
催化二烯化：共轭二烯和多烯立体选择性构建的新兴策略。
DOI：
10.1055/a-1924-2564
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Larionov,OlegV
中科院分区：
文献类型：
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作者：
Ahmed,Jasimuddin;Haug,GrahamC;Nguyen,VietD;Porey,Arka;Trevino,Ramon;Larionov,OlegV
共轭二烯和共轭多烯的立体选择性构建一直是一个持久的合成问题，由于这些化合物在天然产物合成，方法学和医学中发挥的中心作用。本文综述了二烯化反应的最新进展，这是一种直接安装共轭π-体系的不饱和四碳单元的新兴策略，概述了区域和立体选择性，以及与各种二烯化试剂反应的合成范围和用于实现二烯化的催化交叉偶联过程的机理影响。3-二烯4小环二烯基化试剂5吡喃酮、炔和高丙二烯基硼酸酯6结论和展望
Stereoselective construction of conjugated dienes and polyenes has remained an enduring synthetic problem owing to the central roles these compounds play in natural product synthesis, methodology, and medicine. This review focuses on recent developments in dienylation as an emerging strategy for the direct installation of unsaturated four-carbon units of conjugated π-systems, outlining the regio- and stereoselectivity, as well as the synthetic scope of reactions with various dienylating reagents and the mechanistic implications of the catalytic cross-coupling processes that are used to enable dienylation.1 Introduction2 Sulfolenes3 1,3-Dienes4 Small-Ring Dienylation Reagents5 Pyrones, Alkynes, and Homoallenylboronates6 Conclusion and Outlook