MHC Class II Presentation in Autoimmunity.
MHC Class II Presentation in Autoimmunity.
复制标题
自身免疫性的MHC II类介绍。
作者：
主要组织相容性复合体II类（MHC-II）分子的抗原呈递对于激发CD4+ T细胞的有效免疫应答和维持自身抗原耐受性至关重要。已知一些MHC-II等位基因与不同自身免疫性疾病（ADs）的发生风险呈正相关或负相关，包括那些以自身反应性T细胞出现为特征的疾病。显然，自身抗原的MHC-II呈递有助于自身免疫T细胞反应，通过胸腺对自身抗原的中枢耐受的破坏而启动。自身反应性T细胞的出现可能是由于(i) T细胞受体（tcr）和MHC-II上的自身抗原之间的不寻常的相互作用；（ii）自身抗原的翻译后修饰（PTMs）；（iii）直接将自身抗原装载到经典MHC- ii上，无需额外的非经典MHC辅助；（iv）促炎环境对MHC-II表达和抗原提呈的影响；(v)外来抗原和自身抗原之间的分子模仿。MHC-II介导的递呈过程的特殊性可能对阐明ADs的触发和发展机制以及阐明与ADs负相关的MHC-II等位基因的保护作用具有至关重要的意义。
Antigen presentation by major histocompatibility complex class II (MHC-II) molecules is crucial for eliciting an efficient immune response by CD4+ T cells and maintaining self-antigen tolerance. Some MHC-II alleles are known to be positively or negatively associated with the risk of the development of different autoimmune diseases (ADs), including those characterized by the emergence of autoreactive T cells. Apparently, the MHC-II presentation of self-antigens contributes to the autoimmune T cell response, initiated through a breakdown of central tolerance to self-antigens in the thymus. The appearance of autoreactive T cell might be the result of (i) the unusual interaction between T cell receptors (TCRs) and self-antigens presented on MHC-II; (ii) the posttranslational modifications (PTMs) of self-antigens; (iii) direct loading of the self-antigen to classical MHC-II without additional nonclassical MHC assistance; (iv) the proinflammatory environment effect on MHC-II expression and antigen presentation; and (v) molecular mimicry between foreign and self-antigens. The peculiarities of the processes involved in the MHC-II-mediated presentation may have crucial importance in the elucidation of the mechanisms of triggering and developing ADs as well as for clarification on the protective effect of MHC-II alleles that are negatively associated with ADs.
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DOI：
10.1126/science.aad2791
发表时间：
2016-02-12
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Delong T;Wiles TA;Baker RL;Bradley B;Barbour G;Reisdorph R;Armstrong M;Powell RL;Reisdorph N;Kumar N;Elso CM;DeNicola M;Bottino R;Powers AC;Harlan DM;Kent SC;Mannering SI;Haskins K
通讯作者：
Haskins K
影响因子：
32.4
作者：
Adams JJ;Narayanan S;Liu B;Birnbaum ME;Kruse AC;Bowerman NA;Chen W;Levin AM;Connolly JM;Zhu C;Kranz DM;Garcia KC
通讯作者：
Garcia KC
影响因子：
29.7
作者：
Blum JS;Wearsch PA;Cresswell P
通讯作者：
Cresswell P
COVID-19 感染的遗传途径：对风险、严重程度和结果的影响
影响因子：
4.8
作者：
Debnath, Monojit;Banerjee, Moinak;Berk, Michael
通讯作者：
Berk, Michael
影响因子：
5.4
作者：
Collado, Javier A.;Alvarez, Inaki;Jaraquemada, Dolores
通讯作者：
Jaraquemada, Dolores