Intraabdominal schwannomas: A single institution experience
Intraabdominal schwannomas: A single institution experience
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DOI：
10.1007/s11605-007-0441-3
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发表时间：
2008-04-01
影响因子：
3.2
通讯作者：
Wong, Wai-Keong
中科院分区：
文献类型：
--
作者：
Goh, Brian K. P.;Chow, Pierce K. H.;Wong, Wai-Keong
腹腔神经鞘瘤是一种罕见的良性肿瘤。本研究提出了一个单一的机构经验与12个这样的tumors.Methods在1991年至2006年，12例经病理证实的腹腔神经鞘瘤被确定为一系列的216间叶肿瘤，并进行了回顾性reviewed.Results有9名女性和3名男性患者的中位年龄为58岁（范围35-88岁）。11例患者有症状，肿瘤位于胃（n=8），空肠，结肠，直肠和小囊。进行了多种术前检查，包括内镜活检和计算机断层扫描（CT），但均未得出正确的明确术前诊断。中位肿瘤大小为52 mm（范围18-95 mm）。病理检查证实11例胃肠道神经鞘瘤均为实性肿瘤，细胞密度高，由梭形细胞组成，S100蛋白阳性。小囊神经鞘瘤的病理学表现是独特的，因为它表现为囊变伴出血，显微镜下显示典型的软组织神经鞘瘤的Antoni A和B区。所有12例患者中位随访时间为22个月（1-120个月），均无瘤。结论腹腔神经鞘瘤是一种少见的肿瘤，好发于胃肠道。胃肠道神经鞘瘤是很难，如果不是不可能诊断术前内镜和放射学表现是非特异性的。由于诊断的不确定性，治疗的选择是完全手术切除，由于这些病变均为良性，因此长期疗效极佳。
Introduction Intraabdominal schwannomas are rare, benign tumors. This study presents a single institution experience with 12 such tumors.Methods Between 1991 to 2006, 12 patients with a pathologically proven intraabdominal schwannoma were identified from a series of 216 mesenchymal tumors and were reviewed retrospectively.Results There were nine females and three male patients with a median age of 58 years (range 35-88 years). Eleven patients were symptomatic, and the tumors were located in the stomach (n=8), jejunum, colon, rectum, and lesser sac. Multiple preoperative investigations including endoscopies with biopsies and computed tomography (CT) scans were performed, but none yielded a correct definitive preoperative diagnosis. The median tumor size was 52 mm (range 18-95 mm). Pathological examination demonstrated the 11 gastrointestinal tract (GIT) schwannomas to be solid homogenous tumors, which were highly cellular and were composed of spindle cells with positive staining for S100 protein. The pathological appearance of the lesser sac schwannoma was distinct as it demonstrated cystic degeneration with hemorrhage and Antoni A and B areas on microscopy typical of soft tissue schwannomas. All 12 patients were disease-free at a median follow-up of 22 months (range 1-120 months).Conclusion Intraabdominal schwannomas are rare tumors, which are most frequently located within the GIT. GIT schwannomas are difficult if not impossible to diagnose preoperatively as endoscopic and radiologic findings are nonspecific. The treatment of choice is complete surgical excision because of diagnostic uncertainty, and the long-term outcome is excellent as these lesions are uniformly benign.