Locally advanced prostate cancer - Biochemical results from a prospective phase II study of intermittent androgen suppression for men with evidence of prostate-specific antigen recurrence after radiotherapy
Locally advanced prostate cancer - Biochemical results from a prospective phase II study of intermittent androgen suppression for men with evidence of prostate-specific antigen recurrence after radiotherapy
复制标题
DOI：
10.1002/cncr.22464
复制
发表时间：
2007-03-01
期刊：
影响因子：
6.2
通讯作者：
Goldenberg, S. Larry
中科院分区：
文献类型：
--
作者：
Bruchovsky, Nicholas;Klotz, Laurence;Goldenberg, S. Larry
BACKGROUND. Biochemical results from a prospective Phase II trial of intermittent androgen suppression for recurrent prostate cancer after radiotherapy were analyzed for correlations to the onset of hormone - refractory disease.METHODS. Patients with histologically confirmed adenocarcinoma of the prostate and a rising serum prostate- specific antigen (PSA) level after external beam irradiation of the prostate were treated intermittently with a 36-week course of cyproterone acetate and leuprolide acetate. Then, patients were stratified according to their serum PSA range at the start of each cycle and were followed with further biochemical testing until disease progression was evident.RESULTS. The mean PSA reduction was 95.2% irrespective of stratification group. A baseline serum PSA level < 10 mu g/L and a serum PSA nadir = 7.5 nmol/L was observed in 75%, 50%, 40%, and 30% of men in Cycles 1 to 4, respectively, and was sufficient to normalize the level of hemoglobin in each cycle, which dropped by an average of 10.8 g/L during treatment (P < .0001).CONCLUSIONS. The length of the off-treatment interval during cyclic androgen withdrawal therapy was related inversely to baseline and nadir levels of serum PSA. Nadir PSA was a powerful predictor of early progression to androgen independence.
