Cell-cell adhesion: linking Wnt/beta-catenin signaling with partial EMT and stemness traits in tumorigenesis.
Cell-cell adhesion: linking Wnt/beta-catenin signaling with partial EMT and stemness traits in tumorigenesis.
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DOI：
10.12688/f1000research.15782.1
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发表时间：
2018-01-01
期刊：
影响因子：
--
通讯作者：
Ben-Ze'ev, Avri
中科院分区：
文献类型：
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作者：
Basu, Sayon;Cheriyamundath, Sanith;Ben-Ze'ev, Avri
细胞黏附和运动能力的改变被认为是决定侵袭性和转移性肿瘤发展的关键因素。上皮到间充质转化(EMT)过程被认为是肿瘤进展的主要途径，该过程发生在胚胎发育过程中，以及与此相关的癌细胞黏附特性的变化。最近对肿瘤组织和循环肿瘤细胞团的体内研究表明，在肿瘤进展过程中，EMT过程是一个循序渐进的过程，而不是“要么全有，要么全不”的转变。在这篇评论中，我们讨论了细胞黏附和运动以及黏附介导的信号变化的分子机制，以及它们与癌细胞部分EMT状态和获得干细胞特性的关系。
Changes in cell adhesion and motility are considered key elements in determining the development of invasive and metastatic tumors. Co-opting the epithelial-to-mesenchymal transition (EMT) process, which is known to occur during embryonic development, and the associated changes in cell adhesion properties in cancer cells are considered major routes for tumor progression. More recent in vivo studies in tumor tissues and circulating tumor cell clusters suggest a stepwise EMT process rather than an "all-or-none" transition during tumor progression. In this commentary, we addressed the molecular mechanisms underlying the changes in cell adhesion and motility and adhesion-mediated signaling and their relationships to the partial EMT states and the acquisition of stemness traits by cancer cells.