AIDS, drugs of abuse and the immune system: a complex immunotoxicological network.
AIDS, drugs of abuse and the immune system: a complex immunotoxicological network.
复制标题
艾滋病、滥用药物和免疫系统：复杂的免疫毒理学网络。
DOI：
10.1007/bf02098025
复制
发表时间：
1991
影响因子：
6.1
通讯作者：
Watson,RR
中科院分区：
文献类型：
--
作者：
Pillai,R;Nair,BS;Watson,RR
Two of the most interesting questions often asked about AIDS is why many people do not become immunodeficient or get complicating disease when first infected with Human Immunodeficiency Virus (HIV) and what are the “risk factors” making some individuals more susceptible to the disease. A large majority of people with AIDS have a well established history of drug and alcohol abuse. Both drugs of abuse and alcohol have immunotoxic properties as evidenced by a number of studies. These include marked changes in the cellular, humoral and other components of the immune defense mechanism. Such a compromise of the immune system can render it susceptible to the development of AIDS after HIV infection. This paper reviews the evidence suggesting possible links between substance abuse and its immunotoxicology, and their possible roles in the pathogenesis of AIDS.
