Assessing the validity of current mouse genetic models of obsessive-compulsive disorder.
Assessing the validity of current mouse genetic models of obsessive-compulsive disorder.
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DOI：
10.1097/fbp.0b013e32832a80ad
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发表时间：
2009-03
影响因子：
1.6
通讯作者：
Dulawa SC
中科院分区：
文献类型：
--
作者：
Wang L;Simpson HB;Dulawa SC
强迫症（OCD）是一种以不想要的和侵入性的想法，图像或冲动和/或重复行为为特征的疾病。强迫症是残疾的主要原因，然而，这种复杂的，异质性疾病的遗传因素和病理生理机制仍然在很大程度上未知。在过去的十年中，已经开发了许多假定的强迫症小鼠遗传模型，用于研究这种疾病的神经机制和开发新的治疗方法。本文介绍并评价了这些实验制备的日期。使用基因敲除或转基因方法的模型，以及那些研究遗传多样性种群的变化，进行了评估和讨论。
Obsessive–compulsive disorder (OCD) is a disorder characterized by unwanted and intrusive thoughts, images, or impulses and/or repetitive behavior. OCD is a major cause of disability; however, the genetic factors and pathophysiological mechanisms underlying this complex, heterogeneous disorder remain largely unknown. During the past decade, a number of putative mouse genetic models of OCD have been developed for the purpose of studying the neural mechanisms underlying this disorder and developing novel treatments. This review presents and evaluates these experimental preparations to date. Models using knockout or transgenic approaches, as well as those examining variation in genetically diverse populations, are evaluated and discussed.