The synthesis of water soluble isoindoline nitroxides and a pronitroxide hydroxylamine hydrochloride UV-VIS probe for free radicals
The synthesis of water soluble isoindoline nitroxides and a pronitroxide hydroxylamine hydrochloride UV-VIS probe for free radicals
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水溶性异吲哚啉硝基氧和硝基氧原羟胺盐酸盐 UV-VIS 自由基探针的合成
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发表时间：
1998
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影响因子：
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通讯作者：
S. Bottle
中科院分区：
文献类型：
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作者：
D. Reid;S. Bottle
通过对母体氮氧化物2的硝化和对其胺前体1的溴化，制备了新型水溶性氮氧化物5-三甲基胺-1,1,3,3-四甲基异吲哚-2-酰碘8和5-羧基-1,1,3,3-四甲基异吲哚-2-酰碘10；用HCl气体在干燥的EtOH中处理2合成稳定的（1/2 >在甲醇中580 h，生理盐水中72 h）原硝基2-羟基-1,1,3,3-四甲基异吲哚啉盐酸盐6，并与自由基反应生成2；紫外可见光谱可以跟踪该转变。
The novel water soluble nitroxides 5-trimethylammonio-1,1,3,3-tetramethylisoindolin-2-yloxyl iodide 8 and 5-carboxy-1,1,3,3-tetramethylisoindolin-2-yloxyl 10 are prepared by nitration of the parent nitroxide 2 and bromination of its amine precursor 1; the stable (t1/2 > 580 h in MeOH; ca 72 h in physiological saline) pronitroxide 2-hydroxy-1,1,3,3-tetramethylisoindoline hydrochloride 6 was synthesised by treatment of 2 with HCl gas in dry EtOH and reacts with radicals to form 2; the transformation can be followed by UV–VIS spectroscopy.