The influence of menstrual cycle phase on sensitivity to ethanol-like discriminative stimulus effects of GABAA-positive modulators
The influence of menstrual cycle phase on sensitivity to ethanol-like discriminative stimulus effects of GABAA-positive modulators
复制标题
DOI：
10.1016/s0091-3057(99)00057-x
复制
发表时间：
1999-10-01
影响因子：
3.6
通讯作者：
Grant, KA
中科院分区：
文献类型：
--
作者：
Green, KL;Azarov, AV;Grant, KA
以前的研究表明，在月经周期的黄体期，当孕酮水平在训练辨别1.0 g/kg乙醇的猴子中达到峰值时，对别孕烯醇酮和乙醇的乙醇样辨别刺激作用的敏感性增强。本研究进一步探讨了月经周期阶段对乙醇、别孕烯醇酮和咪达唑仑的辨别刺激效应的影响。训练雌性成年食蟹猴（Macaca fascicularis）区分1.0 g/kg乙醇（n = 3）或2.0 g/kg乙醇（n = 4）（20% w/v; IG）与水（IG）。使用累积给药程序来测试在月经周期的卵泡期与黄体期期间乙醇（0.5-2.5 g/kg; IG）的辨别刺激作用和别孕烯醇酮（0.1-1.0 mg/kg; IV）或咪达唑仑（1.0-17 mg/kg; IG）的乙醇样辨别刺激作用。在2.0-g/kg组中，在三只猴子中的两只的黄体期与卵泡期期间，对别孕烯醇酮的乙醇样作用的敏感性增加。相比之下，2.0 g/kg组中黄体期与卵泡期对乙醇的平均敏感性无差异。最后，在接受2.0 g/kg或1.0 g/kg乙醇训练的猴中，卵泡期和黄体期对咪达唑仑的敏感性没有差异。总体而言，咪达唑仑的乙醇样辨别刺激效应对月经周期不敏感。此外，与1.0 g/kg乙醇训练剂量相比，2.0 g/kg的月经周期阶段对别孕烯醇酮和乙醇敏感性的影响较小。(C)1999 Elsevier Science Inc.
Previous studies showed that sensitivity to the ethanol-like discriminative stimulus effects of allopregnanolone and ethanol are enhanced during the luteal phase of the menstrual cycle when progesterone levels peak in monkeys trained to discriminate 1.0 g/kg ethanol. The present study further explored the influence of the menstrual cycle phase on the discriminative stimulus effects of ethanol, allopregnanolone, and midazolam. Female adult cynomolgus monkeys (Macaca fascicularis) were trained to discriminate 1.0 g/kg ethanol (n = 3) or 2.0 g/kg ethanol (n = 4) (20% w/v; IG) from water (IG). A cumulative dosing procedure was used to test discriminative stimulus effects of ethanol (0.5-2.5 g/kg; IG) and the ethanol-like discriminative stimulus effects of allopregnanolone (0.1-1.0 mg/kg; IV) or midazolam (1.0-17 mg/kg; IG) during the follicular vs. luteal phase of the menstrual cycle. In the 2.0-g/kg group, sensitivity to the ethanol- like effects of allopregnanolone was increased during the luteal vs. follicular phase in two of three monkeys. In contrast, average sensitivity to ethanol was not different in the luteal compared to the follicular phase in the 2.0-g/kg group. Finally, there was no difference in sensitivity to midazolam between the follicular and luteal phases in monkeys trained with either 2.0 g/kg or 1.0 g/kg ethanol. Overall, the ethanol-like discriminative stimulus effects of midazolam are not sensitive to the menstrual cycle phase. In addition, there was less influence of the menstrual cycle phase on allopregnanolone and ethanol sensitivity in a 2.0-g/kg compared to a 1.0-g/kg ethanol training dose. (C) 1999 Elsevier Science Inc.