Post-translational Modifications in Heart Failure: Small Changes, Big Impact.
Post-translational Modifications in Heart Failure: Small Changes, Big Impact.
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DOI：
10.1016/j.hlc.2015.11.008
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发表时间：
2016-04
期刊：
影响因子：
--
通讯作者：
Kho C
中科院分区：
文献类型：
--
作者：
Lee A;Oh JG;Gorski PA;Hajjar RJ;Kho C
心力衰竭是一种具有多种病因的复杂疾病过程，并且是世界范围内发病和死亡的重要原因。翻译后修饰（PTM）改变蛋白质结构，并提供心脏生理功能方面的功能多样性。此外，蛋白质PTM的改变与人类疾病发病机制有关。小泛素样修饰物介导的修饰（SUMO化）途径在心脏发育和功能中发挥重要作用。SUMO化异常已成为心力衰竭病理学的一个新特征。在这篇综述中，我们将强调SUMO化作为SERCA2a功能的调节机制的重要性，以及其在心力衰竭治疗中的治疗潜力。
Heart failure is a complex disease process with various aetiologies and is a significant cause of morbidity and death world-wide. Post-translational modifications (PTMs) alter protein structure and provide functional diversity in terms of physiological functions of the heart. In addition, alterations in protein PTMs have been implicated in human disease pathogenesis. Small ubiquitin-like modifier mediated modification (SUMOylation) pathway was found to play essential roles in cardiac development and function. Abnormal SUMOylation has emerged as a new feature of heart failure pathology. In this review, we will highlight the importance of SUMOylation as a regulatory mechanism of SERCA2a function, and its therapeutic potential for the treatment of heart failure.