Non-specific psychological distress in women undergoing noninvasive prenatal testing because of advanced maternal age
Non-specific psychological distress in women undergoing noninvasive prenatal testing because of advanced maternal age
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DOI：
10.1002/pd.4427
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发表时间：
2014-11-01
影响因子：
3
通讯作者：
Sugiura-Ogasawara, Mayumi
中科院分区：
文献类型：
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作者：
Suzumori, Nobuhiro;Ebara, Takeshi;Sugiura-Ogasawara, Mayumi
目的本研究的目的是描述我们为孕妇提供胎儿非整倍体的无创产前检测（NIPT）的临床经验，突出显示非特异性心理困扰的程度。方法收集日本妇女的数据，这些妇女在遗传咨询后接受了NIPT，并对照未接受NIPT的孕妇，作为日本环境和儿童研究控制计划的一部分。使用Kessler 6 （K6）筛选量表评估精神痛苦程度，得分为10分表示抑郁或焦虑障碍。结果505例高龄产妇中，K6评分为10分的占9.1%。与匹配对照组（n=1010）相比，经产妇年龄和胎龄调整后，NIPT组的K6评分有较高的趋势（优势比1.44,95%可信区间0.97-2.13，P=0.07）。在NIPT咨询中，丈夫是主要决策者的女性，其K6得分越高（P=0.06）。结论选择NIPT的女性抑郁/焦虑得分较高，且抑郁得分较高的女性倾向于将选择NIPT的决定推迟给丈夫。(c) 2014 John Wiley & Sons, Ltd。
ObjectiveThe objective of our study was to describe our clinical experience in providing noninvasive prenatal testing (NIPT) for fetal aneuploidy to pregnant women, highlighting the degree of non-specific psychological distress.MethodsData were collected from Japanese women who were offered and underwent NIPT after genetic counseling and control pregnant women who did not undergo NIPT as part of the Japan Environment and Children's Study Control A planning. The degree of mental distress was assessed using the Kessler 6 (K6) screening scale with a score of 10 indicating depression or anxiety disorder.ResultsAmong the 505 women who underwent NIPT because of advanced maternal age, 9.1% had a K6 score of 10. Compared with matched controls (n=1010) adjusted for maternal age and gestational age, the NIPT group showed a trend toward higher K6 scores (odds ratio 1.44, 95% confidence interval 0.97-2.13, P=0.07). Higher K6 scores were associated with women whose husbands were the primary decision makers during NIPT counseling (P=0.06).ConclusionsWomen electing NIPT tend to have higher scores of depression/anxiety, and those with higher depression scores tended to defer the decision to their husbands. (c) 2014 John Wiley & Sons, Ltd.