Repeatability of Ultrasound-Defined Bladder Shape Metrics in Healthy Volunteers.
Repeatability of Ultrasound-Defined Bladder Shape Metrics in Healthy Volunteers.
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DOI：
10.2147/rru.s351347
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发表时间：
2022
影响因子：
1.6
通讯作者：
Speich, John E.
中科院分区：
文献类型：
--
作者：
Maddra, Kaitlyn M.;Li, Rui;Nagle, Anna S.;Klausner, Adam P.;Speich, John E.
最近的研究证明了使用非侵入性腹部超声来量化膀胱形状及其与膀胱充盈和排尿障碍的关系的潜在价值。本研究的目的是评估同一个体在多次膀胱充盈和研究访视中超声波定义的膀胱形状指标的可重复性。健康志愿者完成了口服补水方案，每周两次就诊，每次都有两个连续的膀胱充空周期，为每位参与者提供了四次总充盈次数。在整个填充过程中，每隔 5 分钟记录一次 3 维 (3-D) 超声图像。使用 GE 4D-View 软件在六个相距 30° 的横截面中手动追踪周界。横向、矢状和冠状平面的直径、周长和横截面积根据 200、300 和 400mL 三个标准膀胱体积进行插值。为了量化重复性，计算了每个标准体积下每个指标的组内相关系数 (ICC) 和归一化平均绝对差。中等和良好重复性分别定义为 ICC ≥0.5 和 ICC ≥0.75。分析了 16 名健康志愿者（9 名女性，7 名男性）的数据。横向垂直和水平直径的 ICC 显示出良好的重复性，九个周边 ICC 中的五个显示出中等或良好的重复性。所有周长测量的平均绝对差/平均比率≤4%，表明多次填充和访问的重复性是一致的。初步证据表明，膀胱形状指标相对可重复，因此可以作为潜在评估膀胱功能的非侵入性工具。
Recent studies demonstrate the potential value of using non-invasive abdominal ultrasound to quantify bladder shape and its association with disorders of bladder filling and voiding. The aim of the present study was to assess the repeatability of ultrasound-defined bladder shape metrics within the same individual from multiple bladder fills and study visits. Healthy volunteers completed an oral hydration protocol with two weekly visits, each with two consecutive bladder fill-void cycles, providing four total fills per participant. Throughout filling, 3-dimensional (3-D) ultrasound images were recorded at 5-minute intervals. Perimeters were manually traced in six cross-sectional planes 30° apart using GE 4D-View software. Diameters, perimeters and cross-sectional areas for the transverse, sagittal and coronal planes were interpolated at three standard bladder volumes of 200, 300, and 400mL. To quantify repeatability, intraclass correlation coefficients (ICCs) and normalized mean absolute differences were calculated for each metric at each standard volume. Moderate and good repeatability were defined as ICC ≥0.5 and ICC ≥0.75, respectively. Data from 16 healthy volunteers (9 females, 7 males) were analyzed. ICCs for the transverse vertical and horizontal diameters showed good repeatability, and five of nine perimeter ICCs showed moderate or good repeatability. The mean absolute difference/mean ratio was ≤4% for all perimeter measurements, indicating repeatability was consistent for multiple fills and visits. Initial evidence indicates that bladder shape metrics are relatively repeatable and therefore feasible to pursue as a non-invasive tool for potential evaluation of bladder function.