Haemodynamic and cardiac effects of kinin B-1 and B-2 receptor stimulation in conscious instrumented dogs
Haemodynamic and cardiac effects of kinin B-1 and B-2 receptor stimulation in conscious instrumented dogs
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DOI：
10.1111/j.1476-5381.1996.tb15322.x
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发表时间：
1996-04-01
影响因子：
7.3
通讯作者：
Pruneau, D
中科院分区：
文献类型：
--
作者：
Belichard, P;Loillier, B;Pruneau, D
1 杂种犬长期在左冠状动脉周围安装主动脉内导管、Konigsberg 心室内压力传感器和多普勒血流探头。用六甲铵阻断神经节后，在存在或不存在特定拮抗剂的情况下，研究了缓激肽 B-1 和 B-2 受体激动剂 des-Arg(9)-缓激肽和缓激肽 (BK) 的心血管作用。还检查了一氧化氮 (NO) 和前列腺素类对激肽心血管作用的贡献。2 BK (1 μ g kg(-1) min(-1)) 和 des-Arg(9)-BK (1 μ g kg(-1) min(-1)) 均以 2 分钟静脉注射形式给药。输注后，平均动脉压（MAP，BK为-34+/-4%，des-Arg(9)-BK为-45+/-2%）和冠状血管阻力（CVR，BK为-37+/-5%，des-Arg(9)-BK为-50+/-2%）显着降低，而不影响心肌收缩力、左心室舒张末压和冠状动脉速度。与 des-Arg(9)-BK 相比，BK 导致 MAP 和 CVR 显着更大的降低（P
1 Mongrel dogs were chronically instrumented with an intra-aortic catheter, a Konigsberg intraventricular pressure transducer and a Doppler flow probe around the left coronary artery. After ganglionic blockade with hexamethonium, the cardiovascular effects of bradykinin B-1 and B-2 receptor agonists, des-Arg(9)-bradykinin and bradykinin (BK), were investigated in the presence and absence of specific antagonists. The contribution of nitric oxide (NO) and prostanoids to the cardiovascular effects of kinins was also examined.2 BK (1 mu g kg(-1) min(-1)) and des-Arg(9)-BK (1 mu g kg(-1) min(-1)) both given as a 2 min i.v. infusion, produced a significant decrease in mean arterial pressure (MAP, -34+/-4% for BK and -45+/-2% for des-Arg(9)-BK) and coronary vascular resistance (CVR, -37+/-5% for BK and -50+/-2% for des-Arg(9)-BK), without affecting cardiac contractility, left ventricular end diastolic pressure, and coronary velocity. BK caused a significantly greater decrease in MAP and CVR than des-Arg(9)-BK (P