Myocardial perfusion and function in dogs with moderate coronary stenosis
Myocardial perfusion and function in dogs with moderate coronary stenosis
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DOI：
10.1002/mrm.1910350519
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发表时间：
1996-05-01
影响因子：
3.3
通讯作者：
Axel, L
中科院分区：
文献类型：
--
作者：
Kraitchman, DL;Wilke, N;Axel, L
采用聚赖氨酸- gd - dtpa首次增强对比和空间磁化调制（SPAMM）心肌标记进行MRI研究，以评估联合区域心肌血流和二维变形检查的可行性。仪器封闭胸犬在基线控制状态（Cntl）下进行成像，随后进行两种干预：左前降段（LAD）部分闭塞导致的中度冠状动脉狭窄（St）和多巴酚丁胺负荷（StD）导致的中度冠状动脉狭窄（St），基于对比增强MR图像信号强度时间曲线的上坡，仅多巴酚丁胺负荷显示心肌前区（ANT）相对于后壁（POS）灌注不足（LAD分布）（ANT:POS Cntl = 1.077 +/- 0.15 vs ANT:POS StD = 0.477 +/- 0.11）。P < 0.03)，并通过放射性标记微球测量证实（ANT:POS Cntl = 1.18 +/- 0.2 ml/min/g, ANT:POS StD = 0.44 +/- 0.1 ml/min/g, P < 0.002）。局部心肌缩短仅在StD状态下发生显著变化（P < 0.02）；多巴酚丁胺负荷使前区心肌缩短受损（P = NS），而与Cntl相比，未受影响的POS区心肌缩短明显增加（Cntl = 0.964 +/- 0.02 vs StD = 0.884 +/- 0.03, P < 0.001）。这些结果表明，使用超快MRI可以无创地进行局部心肌功能的综合定量评估和心肌血流量的半定量评估。
MRI studies of first-pass contrast enhancement with polylysine-Gd-DTPA and myocardial tagging using spatial modulation of magnetization (SPAMM) were performed to assess the feasibility of a combined regional myocardial blood flow and 2D deformation exam, Instrumented closed-chest dogs were imaged at a baseline control state (Cntl) followed by two interventions: moderate coronary stenosis (St) achieved by partial occlusion of the left anterior descending (LAD) and moderate coronary stenosis with dobutamine loading (StD), Hypoperfusion of the anterior region (ANT) of the myocardium (LAD distribution) relative to the posterior wall (POS) based on the upslope of the signal intensity time curve from the contrast-enhanced MR images was demonstrated only with dobutamine loading (ANT:POS Cntl = 1.077 +/- 0.15 versus ANT:POS StD = 0.477 +/- 0.11, P < 0.03) and was confirmed with radiolabeled microspheres measurements (ANT:POS Cntl = 1.18 +/- 0.2 ml/min/g versus ANT:POS StD = 0.44 +/- 0.1 ml/min/g; P < 0.002). Significant changes in regional myocardial shortening were only seen in the StD state (P < 0.02); the anterior region showed impaired myocardial shortening with dobutamine loading (P = NS), whereas the nonaffected POS region showed a marked increase in shortening when compared with Cntl (Cntl = 0.964 +/- 0.02 versus StD = 0.884 +/- 0.03; P < 0.001). These results demonstrate that an integrated quantitative assessment of regional myocardial function and semiquantitative assessment of myocardial blood flow can be performed noninvasively with ultrafast MRI.