Dynamic causal modelling of auditory surprise during disconnected consciousness: The role of feedback connectivity.
Dynamic causal modelling of auditory surprise during disconnected consciousness: The role of feedback connectivity.
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DOI：
10.1016/j.neuroimage.2022.119657
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发表时间：
2022-11
期刊：
影响因子：
5.7
通讯作者：
Sanders, Robert D.
中科院分区：
文献类型：
--
作者：
Casey, Cameron P.;Tanabe, Sean;Farahbakhsh, Zahra;Parker, Margaret;Bo, Amber;White, Marissa;Ballweg, Tyler;Mcintosh, Andrew;Filbey, William;Banks, Matthew I.;Saalmann, Yuri B.;Pearce, Robert A.;Sanders, Robert D.
尽管对该领域至关重要，但麻醉期间个体对其环境失去感觉意识的神经机制仍然知之甚少。先前的研究并没有区分对环境的感官意识（连通性）和意识本身。在目前的研究中，我们调查了感官意识的神经相关性，通过对比神经反应的听觉漫游古怪的范式在意识与感官意识（连接意识）和意识没有感官意识（断开意识）。这些状态是使用镇静剂α 2肾上腺素能激动剂右美托咪定的连续觉醒范例捕获的，根据我们发表的假设选择，即抑制去甲肾上腺素信号传导是诱导感觉断开状态的关键。在右美托咪定给药前后记录了18例人类受试者的高密度脑电图。通过研究事件相关电位，并利用动态因果模型（DCM）的进步，我们评估了以前建立的听觉处理网络的节点之间的有效连接的改变。我们发现，在断开的意识，头皮水平的反应，以标准的音调产生了P3的反应，是在连接的意识缺席。这种P3反应类似于在连接意识中看到的对古怪音调的反应。DCM表明，断开连接会增加整个听觉网络中的标准音调反馈信号。模拟分析表明，这些变化的连接，最显着的增加，从右上级颞回的反馈到右A1，可以解释新的P3反应。这些发现表明，在意识断开期间，正常的预测编码过程会中断，因此所有传入的听觉刺激都会变得同样令人惊讶。
The neural mechanisms through which individuals lose sensory awareness of their environment during anesthesia remains poorly understood despite being of vital importance to the field. Prior research has not distinguished between sensory awareness of the environment (connectedness) and consciousness itself. In the current study, we investigated the neural correlates of sensory awareness by contrasting neural responses to an auditory roving oddball paradigm during consciousness with sensory awareness (connected consciousness) and consciousness without sensory awareness (disconnected consciousness). These states were captured using a serial awakening paradigm with the sedative alpha2 adrenergic agonist dexmedetomidine, chosen based on our published hypothesis that suppression of noradrenaline signaling is key to induce a state of sensory disconnection. High-density electroencephalography was recorded from 18 human subjects before and after administration of dexmedetomidine. By investigating event-related potentials and taking advantage of advances in Dynamic Causal Modeling (DCM), we assessed alterations in effective connectivity between nodes of a previously established auditory processing network. We found that during disconnected consciousness, the scalp-level response to standard tones produced a P3 response that was absent during connected consciousness. This P3 response resembled the response to oddball tones seen in connected consciousness. DCM showed that disconnection produced increases in standard tone feedback signaling throughout the auditory network. Simulation analyses showed that these changes in connectivity, most notably the increase in feedback from right superior temporal gyrus to right A1, can explain the new P3 response. Together these findings show that during disconnected consciousness there is a disruption of normal predictive coding processes, so that all incoming auditory stimuli become similarly surprising.
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影响因子：
3.7
作者：
Attal Y;Schwartz D
通讯作者：
Schwartz D
影响因子：
8.8
作者：
Blain-Moraes S;Tarnal V;Vanini G;Alexander A;Rosen D;Shortal B;Janke E;Mashour GA
通讯作者：
Mashour GA
影响因子：
5.7
作者：
Doelling, Keith B.;Arnal, Luc H.;Ghitza, Oded;Poeppel, David
通讯作者：
Poeppel, David
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
3.7
作者：
Groppe DM;Urbach TP;Kutas M
通讯作者：
Kutas M