Statistical tests of neutrality of mutations against population growth, hitchhiking and background selection.
Statistical tests of neutrality of mutations against population growth, hitchhiking and background selection.
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作者：
Yunxin Fu
这篇文章的主要目的是提出几个新的统计检验的中性突变对一类替代模型，在这种模型下，DNA多态性往往表现出过剩的罕见等位基因或年轻的突变。另一个目的是研究现有的和新开发的测试的权力，并检查在人口增长，遗传搭便车和背景选择的多态性的详细模式。它被发现，在一个DNA样本的多态性模式下的逻辑人口增长和遗传搭便车是非常相似的，新开发的测试之一，Fs，是相当强大的比现有的测试拒绝突变的中性假设。背景选择产生的多态性模式与逻辑种群增长或遗传搭便车产生的多态性模式完全不同，尽管它们都显示出稀有等位基因或年轻突变的过剩。我们表明，傅和李的测试是最强大的测试对背景选择。这些结果的影响进行了讨论。
The main purpose of this article is to present several new statistical tests of neutrality of mutations against a class of alternative models, under which DNA polymorphisms tend to exhibit excesses of rare alleles or young mutations. Another purpose is to study the powers of existing and newly developed tests and to examine the detailed pattern of polymorphisms under population growth, genetic hitchhiking and background selection. It is found that the polymorphic patterns in a DNA sample under logistic population growth and genetic hitchhiking are very similar and that one of the newly developed tests, Fs, is considerably more powerful than existing tests for rejecting the hypothesis of neutrality of mutations. Background selection gives rise to quite different polymorphic patterns than does logistic population growth or genetic hitchhiking, although all of them show excesses of rare alleles or young mutations. We show that Fu and Li's tests are among the most powerful tests against background selection. Implications of these results are discussed.