Gluconeogenesis in Weanling Rats with Hypothalamic Obesity*
Gluconeogenesis in Weanling Rats with Hypothalamic Obesity*
复制标题
下丘脑肥胖断奶大鼠的糖异生*
DOI：
10.1055/s-0028-1093767
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发表时间：
1975
影响因子：
2.2
通讯作者：
J. Gold
中科院分区：
文献类型：
--
作者：
L. Goldman;L. Bernardis;Dr. W.M. Hunter;J. Gold
本文测定了下丘脑腹内侧核（VMN）损伤致肥胖和非肥胖断乳大鼠肾切除前后血浆尿素浓度、体内碳酸氢根和丙氨酸掺入肝糖原和血浆葡萄糖及体外丙氨酸掺入肝葡萄糖的变化。肥胖大鼠的基础尿素水平较高，肾切除术后比正常大鼠上升更快。与对照组大鼠相比，进食肥胖大鼠的肝糖原和血糖中的Biclavin掺入量更大。禁食增加纳入肝糖原在这两个群体中，但纳入血浆葡萄糖禁食增加控制比肥胖大鼠。在体内，肥胖大鼠肝糖原和血浆葡萄糖中丙氨酸的掺入量高于正常大鼠，但在体外，肝切片中丙氨酸向葡萄糖的转化率无明显差异。这些结果表明，下丘脑性肥胖的断乳大鼠中的神经发生增加。VMN损伤的产生引发这一系列事件的确切信号仍然未知。
The plasma concentration of urea before and after nephrec tomy, the in vivo incorporation of bicarbonate and alanine in to Iiver glycogen and plasma glucose, and the in vitro incorpo ration of alanine into Iiver glucose were measured in wean-Iing rats with and without obesity induced by ventromedial hypothalamic (VMN) lesions. Basal urea levels were higher in obese rats and rose more rapidly than normal after nephrec tomy. Bicarbonate incorporation into Iiver glycogen and plasma glucose was greater in fed obese than in fed control rats. Fasting increased incorporation into Iiver glycogen in both groups, but the incorporation into plasma glucose was increased by fasting much more in control than obese rats. Obese rats incorporated more alanine than normal into Iiver glycogen and plasma glucose in vivo, but in vitro there was nb observable difference in alanine conversion to glu cose by the Iiver slice. These results indicate that gluconeo genesis is increased in \li\lo in the weanling rat with hypo thalamic obesity. The precise signal by wh ich the produc tion of VMN lesions initiates this sequence of events remains unknown.