Crystal structure analysis of deamino-oxytocin: conformational flexibility and receptor binding.
Crystal structure analysis of deamino-oxytocin: conformational flexibility and receptor binding.
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DOI：
10.1126/science.3008332
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发表时间：
1988-04
期刊：
影响因子：
56.9
通讯作者：
Steve P. Wood;I. Tickle;A. Treharne;J. Pitts;Y. Mascarenhas;Y. Mascarenhas;J.-Y. Li;Jasmine Husain;S. Cooper;Tom L. Blundell;V. J. Hruby;A. Buku;A. J. Fischman;H. Wyssbrod
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文献类型：
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作者：
Steve P. Wood;I. Tickle;A. Treharne;J. Pitts;Y. Mascarenhas;Y. Mascarenhas;J.-Y. Li;Jasmine Husain;S. Cooper;Tom L. Blundell;V. J. Hruby;A. Buku;A. J. Fischman;H. Wyssbrod
通过同晶置换和反常散射X射线测量，确定了两种脱氨基催产素的晶体结构，其分辨率优于1.1A。在两种晶型中，存在两种具有不同手性的二硫桥的密切相关的构象异构体，其在受体识别和活化中可能是重要的。
Two crystal structures of deamino-oxytocin have been determined at better than 1.1A resolution from isomorphous replacement and anomalous scattering x-ray measurements. In each of two crystal forms there are two closely related conformers with disulfide bridges of different chirality, which may be important in receptor recognition and activation.