Association of diabetes mellitus and chronic hepatitis C virus infection
Association of diabetes mellitus and chronic hepatitis C virus infection
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DOI：
10.1002/hep.510290235
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发表时间：
1999-02-01
期刊：
影响因子：
13.5
通讯作者：
Perrillo, RP
中科院分区：
文献类型：
--
作者：
Mason, AL;Lau, JYN;Perrillo, RP
虽然已知肝病患者葡萄糖耐受不良的患病率较高，但初步研究表明，丙型肝炎病毒（HCV）感染可能是糖尿病发展的额外危险因素。为了进一步研究HCV感染与糖尿病的相关性，我们对1，117例慢性病毒性肝炎患者进行了回顾性分析，并分析了年龄、性别、种族、B型肝炎病毒（HBV）感染、HCV感染和肝硬化与糖尿病独立相关。此外，还进行了一项病例对照研究，以确定594名糖尿病患者和377名甲状腺疾病门诊患者的HCV感染血清阳性率。在前一项研究中，在排除了易患高血糖症的患者后，在21%的HCV感染患者中观察到糖尿病，而在12%的HBV感染患者中观察到糖尿病（P = .0004），多因素分析显示，HCV感染（P = 0.02）年龄（P =.01）是糖尿病的独立预测因子，在糖尿病队列中，4.2%的患者被发现感染HCV，而对照组为1.6%（P = 0.02），HCV基因型2a在HCV-RNA阳性的糖尿病患者中为29%，而当地HCV感染的对照组为3%（P
While patients with liver disease are known to have a higher prevalence of glucose intolerance, preliminary studies suggest that hepatitis C virus (HCV) infection may be an additional risk factor for the development of diabetes mellitus, To further study the correlation of HCV infection and diabetes, we performed a retrospective analysis of 1,117 patients with chronic viral hepatitis and analyzed whether age, sex, race, hepatitis B virus (HBV) infection, HCV infection, and cirrhosis were independently associated with diabetes. In addition, a case-control study was conducted to determine the seroprevalence of HCV infection in a cohort of 594 diabetics and 377 clinic patients assessed for thyroid disease. In the former study after the exclusion of patients with conditions predisposing to hyperglycemia, diabetes was observed in 21% of HCV-infected patients compared with 12% of HBV-infected subjects (P = .0004), Multivariate analysis revealed that HCV infection (P =.02) and age (P =.01) were independent predictors of diabetes, In the diabetes cohort, 4.2% of patients were found to be infected with HCV compared with 1.6% of control patients (P =.02), HCV genotype 2a was observed in 29% of HCV-RNA-positive diabetic patients versus 3% of local HCV-infected controls (P