Growth hormone treatment in pediatric burns: a safe therapeutic approach.
Growth hormone treatment in pediatric burns: a safe therapeutic approach.
复制标题
小儿烧伤的生长激素治疗：一种安全的治疗方法。
DOI：
10.1097/00000658-199810000-00001
复制
发表时间：
1998
影响因子：
9
通讯作者：
Herndon,DN
中科院分区：
文献类型：
--
作者：
Ramirez,RJ;Wolf,SE;Barrow,RE;Herndon,DN
Objective To determine the safety and efficacy of recombinant human growth hormone (rhGH) in the treatment of children who are severely burned.Summary Background Data During the last decade, we have used recombinant human growth hormone (rhGH; 0.2 mg/kg/day SQ) to successfully treat 130 children with more than 40% total body surface area (TBSA) burns to enhance wound healing and decrease protein loss. A significant increase in the mortality of adult patients in the intensive care unit who were given rhGH has recently been reported in two large European trials which questions the therapeutic safety of rhGH.Methods The records of 263 children who were burned were reviewed. Patients receiving either rhGH at 0.2 mg/kg/day subcutaneously as part of a randomized clinical trial (n= 48) or therapeutically (n= 82) were compared with randomized placebo-administered controls (n= 54), contiguous matched controls (n= 48), and matched patients admitted after August 1997, after which no patients were treated with rhGH (n= 31). Morbidity and mortality, which might be altered by rhGH therapy, were considered with specific attention to organ function or failure, infection, hemodynamics, and calcium, phosphorous, and albumin balance.Results A 2% mortality was observed in both rhGH and saline placebo groups in the controlled studies, with no differences in septic complications, organ dysfunction, or heart rate pressure product identified. In addition, no difference in mortality could be shown for those given rhGH therapeutically versus their controls. No patient deaths were attributed to rhGH in autopsies reviewed by observers blinded to treatment. Hyperglycemic episodes and exogenous insulin requirements were higher among rhGH recipients, whereas exogenous albumin requirements and the development of hypocalcemia was reduced.Conclusions Data indicate that rhGH used in the treatment of children who were severely burned is safe and efficacious.
登录
查看更多内容
影响因子：
9
作者：
GILPIN, DA;BARROW, RE;HERNDON, DN
通讯作者：
HERNDON, DN
增加严重热损伤后的存活率
DOI：
10.1097/00005373-199509000-00021
发表时间：
1994
影响因子：
--
作者：
J. Knox;R. Demling;D. Wilmore;P. Sarraf;Alfred A. Santos
通讯作者：
Alfred A. Santos
通过佐剂重组人生长激素增强胃肠外喂养的创伤受害者的蛋白质合成效率。
DOI：
--
发表时间：
1993
期刊：
Journal of Trauma
影响因子：
--
作者：
S. Petersen;N. J. Holaday;M. Jeevanandam
通讯作者：
M. Jeevanandam
目前的治疗方法可以减少烧伤儿科患者维持体重所需的热量。
DOI：
--
发表时间：
1990
期刊：
Journal of Burn Care and Rehabilitation
影响因子：
--
作者：
M. Hildreth;D. Herndon;M. Desai;L. Broemeling
通讯作者：
L. Broemeling
影响因子：
2.7
作者：
D. Baller;H. Bretschneider;G. Hellige
通讯作者：
G. Hellige