A randomized controlled bicenter trial of yoga for patients with colorectal cancer
A randomized controlled bicenter trial of yoga for patients with colorectal cancer
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DOI：
10.1002/pon.3927
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发表时间：
2016-04-01
期刊：
影响因子：
3.6
通讯作者：
Langhorst, Jost
中科院分区：
文献类型：
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作者：
Cramer, Holger;Pokhrel, Bijay;Langhorst, Jost
本试验的目的是评估瑜伽对结直肠癌患者健康相关的生活质量的影响。MethodsPatients with non-metastatic colorectal cancer.被随机分配到一个为期10周的瑜伽干预（90分钟每周一次）或候补对照组。主要结局指标为第10周时的疾病特异性生活质量（癌症治疗功能评估-结直肠[FACT-C]）。次要结局指标包括FACT-C子量表：精神健康（FACT -精神）;疲劳（FACT -疲劳）;睡眠障碍（匹兹堡睡眠质量量表）;抑郁和焦虑（医院焦虑和抑郁量表）;身体意识（身体连接量表）;和身体功效预期（身体功效预期量表）。结果进行了评估，在第10周和第22周后randomization.Results54例（平均年龄68.39.7岁）被随机分配到瑜伽（n=27;磨损率22.2%）和对照组（n=27;磨损率18.5%）。瑜伽组的患者平均参加了5.3 +/- 4.0节瑜伽课。在FACT-C总分方面没有发现显著的组间差异，在第22周的情绪幸福感方面发现了组间差异（=1.59; 95% CI= 0.27，2.90; p=0.019），第22周时睡眠障碍（=-1.08; 95%CI =-2.13，-0.03; p=0.043），第10周时焦虑（=-1.14; 95%CI =-2.20，-0.09; p=0.043），第10周时抑郁（=-1.34; 95%CI =-2.61，-0.8; p=0.038）。瑜伽组中没有发生严重的不良事件，而肝转移被诊断为一名患者在control group.ConclusionThis随机试验发现没有影响瑜伽对健康相关的生活质量的结直肠癌患者。鉴于高脱落率和低干预依从性，无法从本试验中得出明确结论。版权所有（c）2015约翰威利父子有限公司
ObjectiveThe aim of this trial was to evaluate the effects of yoga on health-related quality of life in patients with colorectal cancer.MethodsPatients with non-metastatic colorectal cancer were randomly assigned to a 10-week yoga intervention (90min once weekly) or a waitlist control group. Primary outcome measure was disease-specific quality of life (Functional Assessment of Cancer Therapy - Colorectal [FACT-C]) at week 10. Secondary outcome measures included FACT-C subscales: spiritual well-being (FACT - Spirituality); fatigue (FACT - Fatigue); sleep disturbances (Pittsburgh Sleep Quality Inventory); depression and anxiety (Hospital Anxiety and Depression Scale); body awareness (Scale of Body Connection); and body-efficacy expectations (Body-Efficacy Expectations Scale). Outcomes were assessed at week 10 and week 22 after randomization.ResultsFifty-four patients (mean age 68.39.7years) were randomized to yoga (n=27; attrition rate 22.2%) and control group (n=27; attrition rate 18.5%). Patients in the yoga group attended a mean of 5.3 +/- 4.0 yoga classes. No significant group differences for the FACT-C total score were found. Group differences were found for emotional well-being at week 22 (=1.59; 95% CI=0.27,2.90; p=0.019), sleep disturbances at week 22 (=-1.08; 95% CI=-2.13, -0.03; p=0.043), anxiety at week 10 (=-1.14; 95% CI=-2.20, -0.09; p=0.043), and depression at week 10 (=-1.34; 95% CI=-2.61, -0.8; p=0.038). No serious adverse events occurred in the yoga group, while liver metastases were diagnosed in one patient in the control group.ConclusionThis randomized trial found no effects of yoga on health-related quality of life in patients with colorectal cancer. Given the high attrition rate and low intervention adherence, no definite conclusions can be drawn from this trial. Copyright (c) 2015 John Wiley & Sons, Ltd.