The left ventricle in aortic stenosis: evidence for the use of ACE inhibitors
The left ventricle in aortic stenosis: evidence for the use of ACE inhibitors
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DOI：
10.1136/hrt.2005.074112
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发表时间：
2006-03-01
期刊：
影响因子：
5.7
通讯作者：
Chambers, J
中科院分区：
文献类型：
--
作者：
Chambers, J
左心室对主动脉瓣狭窄的反应并不简单。它包括室壁增厚和腔大小变化的组合，并对收缩和舒张功能产生相关影响。除了跨主动脉阻力外，它还由许多因素决定。这些因素包括并存的冠心病和高血压，但也包括性别、年龄和遗传因素。本文将提供证据表明，主动脉瓣狭窄应被视为一种临床综合征，涉及左心室以及主动脉瓣。这意味着在评估和治疗主动脉瓣狭窄时，应优先考虑左心室。
The left ventricular response to aortic stenosis is not simple. It consists of a combination of wall thickening and a change in cavity size with associated effects on systolic and diastolic function. It is determined by numerous factors in addition to the transaortic resistance. These include coexistent coronary disease and hypertension, but also sex, age, and genetic factors. This review will give evidence to suggest that aortic stenosis should be regarded as a clinical syndrome involving the left ventricle as well as the aortic valve. This carries the implication that the left ventricle should be given greater priority when assessing and treating aortic stenosis.