Sexually Dimorphic Associations between Maternal Factors and Human Milk Hormonal Concentrations
Sexually Dimorphic Associations between Maternal Factors and Human Milk Hormonal Concentrations
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DOI：
10.3390/nu12010152
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发表时间：
2020-01-01
期刊：
影响因子：
5.9
通讯作者：
Pundir, Shikha
中科院分区：
文献类型：
--
作者：
Galante, Laura;Lagstrom, Hanna;Pundir, Shikha
虽然母乳成分具有明显的动态性，但我们远未清楚地了解是什么因素导致了这种变化。已知母乳中的激素根据特定的母体表型而变化，但有限的证据表明婴儿也在决定母乳成分中发挥作用。本研究的目的是探讨母乳激素水平与母婴特征之间的相互作用。总共分析了501份来自芬兰STEPS队列研究（健康发育步骤）中招募的母亲的母乳样本。对孕前和孕期的母亲数据、社会经济状况和出生时的婴儿特征进行整理。测定了牛奶中的瘦素、脂联素、胰岛素样生长因子-1和环甘氨酸-脯氨酸。采用多元方差分析（MANOVA）和线性回归进行统计分析。观察到与母亲因素的性别特异性相互作用，如婴儿性别介导的妊娠期糖尿病与乳汁脂联素（p = 0.031）、出生方式与总蛋白（p = 0.003）、母亲教育程度与胰岛素样生长因子-1：环甘氨酸-脯氨酸比值（p = 0.035）之间的关联。我们的研究结果表明，母乳成分的变化与母婴特征和病理生理因素之间的相互作用有关。未来的工作应该扩大这些发现，并进一步探索母乳中的激素分布与婴儿结局之间的联系。
While human milk composition is characterised by marked dynamicity, we are far from having a clear picture of what factors drive this variation. Hormones in human milk are known to vary according to specific maternal phenotypes, but limited evidence shows the infant also has a role in determining milk composition. The present study aimed to investigate the interplay between maternal and infant characteristics in relation to human milk hormonal profile. In total, 501 human milk samples from mothers recruited in the Finnish STEPS cohort study (Steps to the healthy development) were analysed. Pre-pregnancy and pregnancy maternal data, socioeconomic status and infant characteristics at birth were collated. Leptin, adiponectin, insulin-like growth factor-1 and cyclic Glycine-Proline in milk were measured. Multivariate analysis of variance (MANOVA) and linear regression were utilised for statistical analysis. Sex-specific interactions with maternal factors were observed, as the infant sex mediated associations between gestational diabetes and milk adiponectin (p = 0.031), birth-mode and total protein (p = 0.003), maternal education and insulin-like growth factor-1: cyclic Glycine-Proline ratio (p = 0.035). Our results suggest that changes in human milk composition are associated with interactions between maternal and infant characteristics and pathophysiological factors. Future work should expand on these findings and further explore the link between hormonal profiles in human milk and infant outcomes.