Functional Modules in Gametogenesis.
Functional Modules in Gametogenesis.
复制标题
配子发生中的功能模块。
DOI：
10.3389/fcell.2022.914570
复制
发表时间：
2022
影响因子：
5.5
通讯作者：
中科院分区：
文献类型：
--
作者：
配子发生，即卵子和精子的产生，是动物有性繁殖的一个基本过程。在配子发生承诺和性命运决定之后，生殖细胞经历了几个发育过程，使其基因组大小减半，并获得配子的性别特异性特征，包括细胞大小、运动性和细胞极性。然而，目前尚不清楚不同的配子发生过程最初是如何整合的。在硬骨鱼medaka （Oryzias latipes）中，生殖系干细胞在成熟性腺中不断产生卵子和精子，并且在生殖细胞中发现了一个性开关基因，我们发现在承诺配子发生后，不同的途径协同启动配子发生。这唤起了功能模块的概念，其中功能互锁的基因被分组以产生不同的配子特征。模块的各种组合可以让我们解释不同生殖系统的进化，如孤雌生殖和雌雄同体。
Gametogenesis, the production of eggs and sperm, is a fundamental process in sexually reproducing animals. Following gametogenesis commitment and sexual fate decision, germ cells undergo several developmental processes to halve their genomic size and acquire sex-specific characteristics of gametes, including cellular size, motility, and cell polarity. However, it remains unclear how different gametogenesis processes are initially integrated. With the advantages of the teleost fish medaka (Oryzias latipes), in which germline stem cells continuously produce eggs and sperm in mature gonads and a sexual switch gene in germ cells is identified, we found that distinct pathways initiate gametogenesis cooperatively after commitment to gametogenesis. This evokes the concept of functional modules, in which functionally interlocked genes are grouped to yield distinct gamete characteristics. The various combinations of modules may allow us to explain the evolution of diverse reproductive systems, such as parthenogenesis and hermaphroditism.