Multi-approach cysteine detection based on supramolecular transformation induced by G-quadruplexes
Multi-approach cysteine detection based on supramolecular transformation induced by G-quadruplexes
复制标题
基于G-四链体诱导的超分子转化的多方法半胱氨酸检测
DOI：
10.1039/c9ay01323g
复制
发表时间：
2019
影响因子：
3.1
通讯作者：
Tang Yalin
中科院分区：
文献类型：
--
作者：
Yang Dawei;Chen Hongbo;Li Qian;Zhang Xiufeng;Sun Hongxia;Tang Yalin
半胱氨酸(Cys)检测探针的研制对临床诊断具有重要意义。在此，我们设计了一种用于半胱氨酸的比色、手性和荧光多途径检测探针。该探针以G-四链体为模板，调控花菁染料的超分子转化，实现对半胱氨酸的无标记、高选择性检测。它在尿液半胱氨酸测定中的成功应用显示了良好的实际应用前景。
Development of a cysteine (Cys) detection probe is of significant importance in clinical diagnosis. Herein, a colorimetric, chiral and fluorometric multi-approach detection probe for Cys has been designed. This probe utilized G-quadruplexes as a template to regulate the supramolecular transformation of a cyanine dye and achieve label-free and highly selective detection of Cys. Its successful use in urinary Cys measurement demonstrates good promise for practical applications.