Positron emission tomography with 11C-acetate and 18F-FDG in prostate cancer patients
Positron emission tomography with 11C-acetate and 18F-FDG in prostate cancer patients
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DOI：
10.1007/s00259-002-1104-y
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发表时间：
2003-04-01
影响因子：
9.1
通讯作者：
Boerner, AR
中科院分区：
文献类型：
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作者：
Fricke, E;Machtens, S;Boerner, AR
尽管有最先进的方法，如CT、MRI、经直肠超声和氟-18氟脱氧葡萄糖正电子发射断层扫描（F-18-FDG PET），原发性前列腺癌的可视化、复发和转移仍是一个临床相关问题。本研究的目的是评价碳-11醋酸酯和F-18-FDG PET在前列腺癌及其转移的检测中的疗效。采用c -11-醋酸PET对25例原发性前列腺癌、疑似复发或转移性疾病的患者进行随访；其中15例患者接受了F-18-FDG PET检查。调查时，14名患者正在接受抗雄激素治疗。使用C-11-acetate PET检测到病变的患者占20/24(83%)，使用F-18-FDG PET检测到病变的患者占10/15（75%）。根据两次PET扫描的结果，一名患者被诊断为复发性肺癌。远端转移的中位F-18-FDG摄取超过c -11-醋酸盐（SUV=3.2 vs 2.3）。然而，在局部复发和区域淋巴结转移中，c -11-醋酸盐摄取（中位suv分别为2.9和3.8）高于F-18-FDG（中位suv分别为1.0和1.1）。血清PSA水平与c -11-醋酸酯摄取和F-18-FDG摄取呈正相关。c -11-醋酸酯在检测局部复发和区域淋巴结转移方面似乎比F-18-FDG更有用。然而，F-18-FDG在观察远处转移方面似乎更准确。c -11-醋酸酯/F-18-FDG PET联用可能对前列腺癌患者的随访和持续或升高的PSA有一定作用。
Visualisation of primary prostate cancer, its relapse and its metastases is a clinically relevant problem despite the availability of state-of-the-art methods such as CT, MRI, transrectal ultrasound and fluorine-18 fluorodeoxyglucose positron emission tomography (F-18-FDG PET). The aim of this study was to evaluate the efficacy of carbon-11 acetate and F-18-FDG PET in the detection of prostate cancer and its metastases. Twenty-five patients were investigated during the follow-up of primary prostate cancer, suspected relapse or metastatic disease using C-11-acetate PET; 15 of these patients were additionally investigated using F-18-FDG PET. Fourteen patients were receiving anti-androgen treatment at the time of the investigation. Lesions were detected in 20/24 (83%) patients using C-11-acetate PET and in 10/15 (75%) patients using F-18-FDG PET. Based on the results of both PET scans, one patient was diagnosed with recurrent lung cancer. Median F-18-FDG uptake exceeded that of C-11-acetate in distant metastases (SUV=3.2 vs 2.3). However, in local recurrence and in regional lymph node metastases, C-11-acetate uptake (median SUVs=2.9 and 3.8, respectively) was higher than that of F-18-FDG (median SUVs=1.0 and 1.1, respectively). A positive correlation was observed between serum PSA level and both C-11-acetate uptake and F-18-FDG uptake. C-11-acetate seems more useful than F-18-FDG in the detection of local recurrences and regional lymph node metastases. F-18-FDG, however, appears to be more accurate in visualising distant metastases. There may be a role for combined C-11-acetate/F-18-FDG PET in the follow-up of patients with prostate cancer and persisting or increasing PSA.