Analysis of the mouse transcriptome for genes involved in the function of the nervous system
Analysis of the mouse transcriptome for genes involved in the function of the nervous system
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DOI：
10.1101/gr.1135303
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发表时间：
2003-06-01
期刊：
影响因子：
7
通讯作者：
Okazaki, Y
中科院分区：
文献类型：
--
作者：
Gustincich, S;Batalov, S;Okazaki, Y
我们分析了小鼠代表性转录本和蛋白质组中涉及脑功能的分子。我们发现了许多已知大脑基因的全长 cDNA，并发现了已知大脑基因家族的新成员，包括家族 3 G 蛋白偶联受体、电压门控通道和连接蛋白。我们还鉴定了以前未知的分泌性神经活性分子的候选者。大量独特的大脑 EST 的存在表明分子的复杂性还有待探索。编码区包含 CAG 序列的基因列表代表了潜在鉴定遗传性神经系统疾病候选者的第一步。
We analyzed the mouse Representative Transcript and Protein Set for molecules involved in brain function. We found full-length cDNAs of many known brain genes and discovered new members of known brain gene families, including Family 3 G-protein coupled receptors, voltage-gated channels, and connexins. We also identified previously unknown candidates for secreted neuroactive molecules. The existence of a large number of unique brain ESTs suggests an additional molecular complexity that remains to be explored. A list of genes containing CAG stretches in the coding region represents a first step in the potential identification of candidates for hereditary neurological disorders.