Antimicrobial resistance at the human-animal interface in the Pastoralist Communities of Kasese District, South Western Uganda
Antimicrobial resistance at the human-animal interface in the Pastoralist Communities of Kasese District, South Western Uganda
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DOI：
10.1038/s41598-020-70517-w
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发表时间：
2020-09-07
影响因子：
4.6
通讯作者：
Asiimwe, Benon B.
中科院分区：
文献类型：
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作者：
Iramiot, Jacob Stanley;Kajumbula, Henry;Asiimwe, Benon B.
在动物疾病管理中大量使用抗菌剂导致了对微生物耐药性的选择。本研究旨在评估卡塞斯区牧民社区的抗菌素使用情况，并描述与抗菌素耐药性在人与动物之间传播的相关因素。本研究采用混合研究方法。从参与者和牛身上采集直肠拭子，在采集后24小时内用Carry-Blaire运输介质运送到实验室进行培养和药敏，以确定是否携带多重耐药细菌。对兽医官员、兽药供应商、公共和私人卫生设施的负责人以及人类药房和药店的经营者进行了深入的访谈。人类携带多重耐药菌88例(93%)，牛携带76例(80%)。湖滨水的消耗和牛体内携带多重耐药细菌与人类种群中携带多重耐药细菌有关。从人和动物中分离出来的生物中，多重耐药性的流行率很高。多药耐药性在人与动物之间传播的可能性很高。
Intensive usage of antimicrobials in the management of animal diseases leads to selection for resistance among microorganisms. This study aimed to assess antimicrobial use and to describe factors associated with the transmission of antimicrobial resistance between humans and animals in pastoralist communities of Kasese district. A mixed-methods approach was employed in this study. Rectal swabs were collected from the participants and cattle and transported in Carry-Blaire transport medium to the laboratory within 24 h of collection for culture and sensitivity to confirm carriage of multi-drug resistant bacteria. In-depth interviews were conducted among veterinary officers, veterinary drug vendors, human health facility in-charges in both public and private health facilities, and operators of human pharmacies and drug shops. Carriage of multi-drug resistant bacteria among humans was 88 (93%) and 76(80%) among cattle. Consumption of lakeshore water and carriage of multi-drug resistant bacteria in cattle were associated with carriage of multi-drug resistant bacteria in the human population. The prevalence of multi-drug resistance among organisms Isolated from both humans and animals was high. There is a high likelihood of transmission of multi-drug resistance between humans and animals.