SYNTHESIS OF NOVEL IODINATED RADIOLIGANDS WITH HIGH-AFFINITY AND SELECTIVITY FOR CCK-B/GASTRIN RECEPTORS
SYNTHESIS OF NOVEL IODINATED RADIOLIGANDS WITH HIGH-AFFINITY AND SELECTIVITY FOR CCK-B/GASTRIN RECEPTORS
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DOI：
10.1016/0960-894x(95)00435-v
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发表时间：
1995-11-02
影响因子：
2.7
通讯作者：
PRITCHARD, MC
中科院分区：
文献类型：
--
作者：
HORWELL, DC;HUNTER, JC;PRITCHARD, MC
通过在最后一步或倒数第二步引入放射性标记的路线，合成了对CCK-B/胃泌素受体具有高亲和力和选择性的两种非肽放射性碘化配体[I-125]-PD142308和[I-125]-PD142251。描述了两种配体的CCK-A和CCK-B结合亲和力。
The syntheses of two non-peptide radio-iodinated ligands [I-125]-PD142308 and [I-125]-PD142251 with high affinity and selectivity for the CCK-B/gastrin receptor are described via a route which introduces the radiolabel at the final or penultimate step. The CCK-A and CCK-B binding affinities of both ligands are described.