Reproductive tract inflammatory disease in postpartum dairy cows
Reproductive tract inflammatory disease in postpartum dairy cows
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DOI：
10.1017/s1751731114000524
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发表时间：
2014-05-01
期刊：
影响因子：
3.6
通讯作者：
LeBlanc, S. J.
中科院分区：
文献类型：
--
作者：
LeBlanc, S. J.
多达一半的奶牛在产后期患有子宫炎、脓性阴道分泌物、子宫内膜炎或宫颈炎中的至少一种。这些情况是由于对细菌感染的免疫反应不足（未能清除子宫中的致病菌）或持续炎症而导致的，这些炎症会损害而不是增强生殖功能。脂肪的动员程度及其作为代谢燃料的有效利用程度被公认为是代谢性疾病和传染病的危险因素。非酯化脂肪酸的释放对肝脏和免疫功能有直接影响，但也会产生促炎细胞因子（肿瘤坏死因子和白细胞介素 6），从而导致全身炎症和胰岛素抵抗。因此，生殖道炎症性疾病可能是局部和全身炎症刺激和调节以及脂肪代谢调节的作用。更好地了解与胰岛素抵抗以及肝脏和脂肪组织炎症调节相关的变量可能会改善生殖道健康。本文综述了可能导致奶牛产后生殖道炎症性疾病的因素及其相互关系、影响和治疗。
Up to half of dairy cows are affected by at least one of metritis, purulent vaginal discharge, endometritis or cervicitis in the postpartum period. These conditions result from inadequate immune response to bacterial infection (failure to clear pathogenic bacteria from the uterus) or persistent inflammation that impairs rather than enhances reproductive function. The degree of mobilization of fat and how effectively it is used as a metabolic fuel is well recognized as a risk factor for metabolic and infectious disease. Release of non-esterified fatty acids has direct effects on liver and immune function but also produces pro-inflammatory cytokines (tumor necrosis factor and interleukin-6), which contribute to systemic inflammation and to insulin resistance. Therefore, reproductive tract inflammatory disease may be a function of both local and systemic inflammatory stimuli and regulation as well as regulation of fat metabolism. Better understanding of variables associated with insulin resistance and inflammatory regulation in the liver and adipose tissue may lead to improvement of reproductive tract health. This paper reviews factors that may contribute to postpartum reproductive tract inflammatory diseases in dairy cows and their inter-relationships, impacts and treatment.