Avian H5N1 influenza virus infection causes severe pneumonia in the Northern tree shrew (Tupaia belangeri)
Avian H5N1 influenza virus infection causes severe pneumonia in the Northern tree shrew (Tupaia belangeri)
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DOI：
10.1016/j.virol.2019.01.015
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发表时间：
2019-03-01
期刊：
影响因子：
3.7
通讯作者：
Kohara, Michinori
中科院分区：
文献类型：
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作者：
Sanada, Takahiro;Yasui, Fumihiko;Kohara, Michinori
H5N1和H7N9等禽流感病毒通常会引起严重症状，人类死亡率很高。动物模型有助于阐明这些感染的致病性机制。在本研究中，为了扩大北方树鼩（Tupaia belangeri）在流感病毒感染方面的潜在效用，我们评估了图帕亚（Tupaia belangeri） H5N1和H7N9禽流感病毒的致病性。从感染这些病毒的动物的鼻腔、口腔、气管和结膜拭子样本中连续检测到传染性病毒。图帕亚感染H5N1流感病毒引起严重弥漫性肺炎伴发热和体重减轻。H7N9流感病毒感染引起局灶性肺炎。肺炎的严重程度与促炎细胞因子转录水平相关。这些结果表明，图帕亚可以作为禽流感病毒研究的另一种合适的动物模型。
Avian-origin influenza viruses like H5N1 and H7N9 often cause severe symptoms with high mortality in humans. Animal models are useful for clarification of the mechanisms of pathogenicity of these infections. In this study, to expand the potential utility of the Northern tree shrew (Tupaia belangeri) for influenza virus infection, we assessed the pathogenicity of H5N1 and H7N9 avian influenza viruses in tupaia. Infectious virus was detected continuously from nasal, oral, tracheal, and conjunctival swab samples in the animals infected with these viruses. H5N1 influenza virus infection of tupaia caused severe diffuse pneumonia with fever and weight loss. In contrast, H7N9 influenza virus infection caused focal pneumonia. The severity of pneumonia was correlated with proinflammatory cytokine transcript levels. These results indicated that tupaia can be another suitable animal model for avian influenza virus research.