The therapeutic effects of an immunopotentiator, PS-K, on 3-methylcholanthrene-induced autochthonous tumors in C57BL/6 mice in combination with the surgical removal of primary sites
The therapeutic effects of an immunopotentiator, PS-K, on 3-methylcholanthrene-induced autochthonous tumors in C57BL/6 mice in combination with the surgical removal of primary sites
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免疫增强剂 PS-K 结合原发部位手术切除对 C57BL/6 小鼠 3-甲基胆蒽诱导的原发性肿瘤的治疗作用
DOI：
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发表时间：
2004
期刊：
影响因子：
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通讯作者：
Hiroshi Kobayashi
中科院分区：
文献类型：
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作者：
M. Hosokawa;T. Mizukoshi;K. Morikawa;Zhen;Hiroshi Kobayashi
SummaryWe investigated the therapeutic effects of an immunopotentiator PS-K on recurrent or metastatic tumors observed after the surgical removal of MCA-induced primary tumors in autochthonous C57BL/6 mice and on the survival time of treated mice. The MST of mice treated with PS-K at various times (59.8 ∼ 63.4 days) was prolonged as compared with that of mice treated by surgery alone (48.6 days). Local recurrence of tumors was found in 36 of 66 mice (54.6%) treated by surgery alone, whereas it was inhibited significantly (P<0.05) when treatment with PS-K was started 1 day after the surgery and occurred in 22 of 64 mice (34.4%) when PS-K was given for 5 days in 1 week, or in 22 of 66 mice (33.3%) when PS-K was administered twice a week for 7 weeks. The MSTs of mice with local recurrence were also found to be prolonged as compared with those of mice treated by surgery alone (54.8 ∼ 67.5 days vs 49.8 days). The MSTs of mice without tumor recurrence were also prolonged significantly (P<0.05 ∽ 0.001) by combinations of PS-K at various times, although most of the mice died of metastatic tumors even in the groups of mice where a combined treatment with PS-K had been administered. The above findings suggest that the administration of PS-K inhibits the growth of recurrent or metastatic tumor cells in autochthonous mice after the surgical removal of the primary tumors.
PS-K（一种蛋白质结合多糖）对同种异体抗原免疫反应的影响。
DOI：
10.1016/0192-0561(83)90069-3
发表时间：
1983
期刊：
International journal of immunopharmacology
影响因子：
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作者：
Ehrke,MJ;Reino,JM;Eppolito,C;Mihich,E
通讯作者：
Mihich,E