Neuronal responses in social-emotional information processing in impulsive aggressive individuals.
Neuronal responses in social-emotional information processing in impulsive aggressive individuals.
复制标题
冲动攻击性个体社会情感信息处理中的神经元反应。
DOI：
10.1038/s41386-022-01296-3
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
Phan,KLuan
中科院分区：
文献类型：
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作者：
Coccaro,EmilF;Keedy,Sarah;Malina,Michael;Lee,Royce;Phan,KLuan
我们如何感知和解释来自他人行为的信号，被称为社会情绪信息处理（SEIP），是应对社会威胁的关键。冲动性攻击的个体，在行为上，表现出受损的SEIP编码相关的社会刺激，归因于其他人在互动中的意图，并消极地应对潜在的威胁性社会情况。在这项研究中，我们试图探讨如何神经加工之间的差异健康控制（HC）和个人的冲动性攻击行为（个人间歇性爆炸性障碍，I-IED），在一个有效的SEIP范式。45名成年人（19 I-IED，26 HC）参与者在fMRI扫描期间进行了验证的SEIP任务。该任务利用了描述一个人对另一个人的社会模糊但可能具有攻击性（AGG）的行为的视频剪辑，并控制了其中可能不发生攻击性行为（CON）的视频剪辑。SEIP中的行为异常也表现在SEIP检查的每个阶段中分布式网络/大脑区域的神经激活改变中。总的来说，神经反应在SEIP范式的特点是减少歧视AGG与CON视频I-IED相比，HC。这些数据表明，存在受损的神经回路受损的社会认知在个人与IED和突出的潜在神经干预目标受损的社会认知I-IED和其他行为障碍以及。
How we perceive and interpret signals from others’ behavior, known as social-emotional information processing (SEIP), is key when responding to social threat. Impulsively aggressive individuals, behaviorally, demonstrate impaired SEIP for encoding relevant social stimuli, attribution of intent of the other person in the interaction, and responding negatively to potentially threatening social situations. In this study, we sought to explore how neural processing differs between healthy controls (HC) and individuals with impulsive aggressive behavior (individuals with Intermittent Explosive Disorder, I-IED), during a validated SEIP paradigm. Forty-five adults (19 I-IED, 26 HC) participants underwent a validated SEIP tasks during an fMRI scan. The task utilized video clips depicting a socially ambiguous, but possibly aggressive (AGG), act by one person to another and control video clips in which where possibly aggressive act does not occur (CON). Behavioral anomalies in SEIP are also manifest in altered neural activation in distributed networks/brain regions in each phase of SEIP examined. Overall, neural responses during the SEIP paradigm were characterized as reduced discrimination of the AGG vs. CON videos for I-IEDs compared to HCs. These data suggest the presence of compromised neural circuits underlying impaired social cognition in individuals with IED and highlights potential neural targets of intervention for impaired social cognition in I-IED and other behavioral disorders as well.