Losartan improves visceral sensation and gut barrier in a rat model of irritable bowel syndrome
Losartan improves visceral sensation and gut barrier in a rat model of irritable bowel syndrome
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DOI：
10.1111/nmo.13819
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发表时间：
2020-02
影响因子：
3.5
通讯作者：
T. Nozu;Saori Miyagishi;Rintaro Nozu;K. Takakusaki;T. Okumura
中科院分区：
文献类型：
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作者：
T. Nozu;Saori Miyagishi;Rintaro Nozu;K. Takakusaki;T. Okumura
脂多糖（LPS）或重复避水应激（WAS）通过促肾上腺皮质激素释放因子（CRF）和促炎细胞因子诱导内脏异常性疼痛和结肠通透性增高，这被认为是大鼠肠易激综合征（IBS）模型。由于已知氯沙坦可抑制促炎细胞因子释放，我们推测其可改善这些内脏变化。
Lipopolysaccharide (LPS) or repeated water avoidance stress (WAS) induces visceral allodynia and colonic hyperpermeability via corticotropin‐releasing factor (CRF) and proinflammatory cytokines, which is considered to be a rat irritable bowel syndrome (IBS) model. As losartan is known to inhibit proinflammatory cytokine release, we hypothesized that it improves these visceral changes.