In vitro remineralization of human and bovine white-spot enamel lesions by NaF dentifrices: A pilot study.
In vitro remineralization of human and bovine white-spot enamel lesions by NaF dentifrices: A pilot study.
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发表时间：
2011-02
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通讯作者：
R. Karlinsey;A. C. Mackey;T. J. Walker;K. E. Frederick;D. D. Blanken-D.;S. Flaig;E. R. Walker
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作者：
R. Karlinsey;A. C. Mackey;T. J. Walker;K. E. Frederick;D. D. Blanken-D.;S. Flaig;E. R. Walker
这项可行性研究的目的是通过显微硬度和氟摄取分析来评估四种牙膏系统的体外再矿化效果。使用10天的pH循环模型，在体外测试牛和人牙釉质中白斑病变的潜在再矿化。这项研究涉及以下氟化钠硅基牙膏：1)安慰剂(0 Ppm F)，2)500 ppm F，3)1150 ppm F，和4)500 ppm F加功能化磷酸三钙(FTCP)。每天包括四次两分钟的治疗，一次四小时的酸刺激(pH=5.0)，以及在这些事件之间浸泡在人工唾液(pH=7.0)中。循环结束后，对试件进行表面显微硬度(SMH)、釉质氟摄取量(EFU)和横截面显微硬度(CSM)分析。统计分析显示，四组间的再矿化差异显著(ANOVA，LSD，p<；0.05)，与1150ppm F和500ppm F加fTCP牙膏相比，安慰剂和500ppm F牙膏提供的再矿化明显较少。值得注意的是，虽然两种牙釉质类型的CSM测量得出了四组牙釉质的相似曲线，但SMH和EFU显示，与牛牙釉质相比，人牙釉质对500ppm F牙膏组更敏感。这种明显的敏感性可能是由于两种底物之间固有的结构差异所致。
The aim of this feasibility study was to evaluate the in vitro remineralization effects of four dentifrice systems using microhardness and fluoride uptake analyses. In vitro testing for the potential remineralization of the white-spot lesions in bovine and human enamel was performed using a 10-day pH cycling model. The study involved the following NaF silica-based dentifrices: 1) placebo (0 ppm F), 2) 500 ppm F, 3) 1150 ppm F, and 4) 500 ppm F plus functionalized tricalcium phosphate (fTCP). Each day consisted of four two-minute treatments, one four-hour acid challenge (pH = 5.0), and immersion in artificial saliva (pH = 7.0) between these events. After cycling, specimens were analyzed for surface microhardness (SMH), enamel fluoride uptake (EFU), and cross-sectional microhardness (CSM). Statistical analyses revealed significant differences (ANOVA, LSD, p<0.05) among the four groups, with the placebo and 500 ppm F dentifrices providing significantly less remineralization relative to the 1150 ppm F and 500 ppm F plus fTCP dentifrices. Notably, while CSM measurements for both enamel types generated similar profiles for the four groups, SMH and EFU revealed human enamel was more sensitive to the 500 ppm F dentifrice groups compared to bovine enamel. This apparent sensitivity may be due to the inherent structural differences between the two substrates.