An application of monotone functions decomposition to the reconstruction of gene regulatory networks.
An application of monotone functions decomposition to the reconstruction of gene regulatory networks.
复制标题
单调函数分解在基因调控网络重建中的应用。
DOI：
10.1109/iembs.2011.6090676
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Amar,S
中科院分区：
文献类型：
--
作者：
Chang,H;Richard,G;Julius,AA;Belta,C;Amar,S
We describe the reconstruction of a gene regulatory network involved with the Toll-like Receptor signaling pathways. By applying our recent identification algorithm to a time series gene expression dataset, we identify regulatory interactions between genes and construct discrete-time piece-wise affine regulatory functions. Our validation shows that our model predicts the expression levels of the genes involved in the network with good accuracy.
