Pregnancy Increases the Growth Rates of World Health Organization Grade II Gliomas
Pregnancy Increases the Growth Rates of World Health Organization Grade II Gliomas
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DOI：
10.1002/ana.21888
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发表时间：
2010-03-01
影响因子：
11.2
通讯作者：
Taillandier, Luc
中科院分区：
文献类型：
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作者：
Pallud, Johan;Mandonnet, Emmanuel;Taillandier, Luc
12怀孕的11名成年妇女窝藏世界卫生组织（WHO）的II级胶质瘤（GIIGs）怀孕前进行了审查，以解决是否怀孕影响肿瘤生长的放射性直径扩张速度（VDE）的连续磁共振图像的定量方法。与孕前（p < 0.001）和产后（p = 0.012）相比，VDE在妊娠期间显著增加。妊娠增加了GIIGs的放射性生长率。在40%的病例中同时观察到癫痫发作频率增加，25%的病例在分娩后开始进一步的肿瘤治疗。神经网络2010;67：398-404
Twelve pregnancies in 11 adult women harboring World Health Organization (WHO) grade II gliomas (GIIGs) prior to pregnancy were reviewed to address whether pregnancy affects tumor growth using a quantitative approach of the radiological velocity of diametric expansion (VDE) on successive magnetic resonance images. VDE was significantly increased during pregnancy as compared to prepregnancy (p < 0.001) and to postdelivery (p = 0.012) periods. Pregnancy increases the radiological growth rates of GIIGs. An increase in seizure frequency was observed concomitantly in 40% of cases and further oncological treatment was started after delivery in 25% of cases. ANN NEUROL 2010;67:398-404