Classical (adiponectin, leptin, resistin) and new (chemerin, vaspin, omentin) adipocytokines in patients with prediabetes
Classical (adiponectin, leptin, resistin) and new (chemerin, vaspin, omentin) adipocytokines in patients with prediabetes
复制标题
DOI：
10.1515/hmbci-2017-0031
复制
发表时间：
2018-04-01
影响因子：
1
通讯作者：
Kamenov, Zdravko
中科院分区：
文献类型：
--
作者：
Gateva, Antoaneta;Assyov, Yavor;Kamenov, Zdravko
工作背景：在过去的十年中，人们对脂肪组织作为一种内分泌器官越来越感兴趣，脂肪组织分泌许多细胞因子和生物活性介质，这些细胞因子和生物活性介质在胰岛素敏感性、炎症、凝血和动脉粥样硬化的发病机制中发挥作用。这项研究的目的是调查经典的（脂联素，瘦素，β-内酰胺酶）和新的（chemerin、vaspin、omentin）脂肪细胞因子水平在患有前驱糖尿病[空腹血糖受损（IFG）和/或葡萄糖耐量受损（IGT）]的受试者和具有正常血糖的肥胖受试者中。在这项研究中，招募了80名平均年龄为50.4 ± 10.6岁的患者，将41例年龄和体重指数（BMI）相近的肥胖患者分为肥胖组和正常组，肥胖组和糖尿病前期组各39例。与糖尿病前期患者相比，血糖正常受试者的血清脂联素水平显着较高。在我们的研究人群中，脂联素对区分有和无胰岛素抵抗的患者具有良好的鉴别能力[曲线下面积（AUC）= 0.728，p = 0.002]。其他脂肪细胞因子水平在两组之间没有显著差异。代谢综合征（MetS）的患者有显着较低的瘦素水平相比，那些没有MetS（33.03 - 14.94与40.24 - 12.23 ng/mL），这种差异持续调整后的体重和BMI。受试者工作特征（ROC）分析显示，低血清瘦素水平可预测MetS的存在（p = 0.03），AUC = 0.645。结论：血清脂联素水平正常的糖尿病患者明显高于糖尿病前期患者，对区分有无胰岛素抵抗有一定的预测价值。血清瘦素对区分研究人群中有无代谢综合征患者具有良好的预测价值。
Background: In the last decade, there has been an increased interest toward fat tissue as an endocrine organ that secretes many cytokines and bioactive mediators that play a role in insulin sensitivity, inflammation, coagulation and the pathogenesis of atherosclerosis. The aim of this study was to investigate classical (adiponectin, leptin, resistin) and new (chemerin, vaspin, omentin) adipocytokine levels in subjects with prediabetes [impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT)] and obese subjects with normoglycemia.Methods: In this study, 80 patients with a mean age of 50.4 10.6 years were recruited, divided into two groups with similar age and body mass index (BMI) with obesity and normoglycemia (n = 41) and with obesity and prediabetes (n = 39).Results: Serum adiponectin levels were significantly higher in subjects with normoglycemia compared to patients with prediabetes. Adiponectin has a good discriminating power to distinguish between patients with and without insulin resistance in our study population [area under the curve (AUC) = 0.728, p = 0.002]. Other adipocytokine levels were not significantly different between the two groups. The patients with metabolic syndrome (MetS) had significantly lower levels of leptin compared to those without MetS (33.03 14.94 vs. 40.24 12.23 ng/mL) and this difference persisted after adjustment for weight and BMI. Receiver operating characteristic (ROC) analysis showed that low serum leptin can predict the presence of MetS (p = 0.03), AUC = 0.645.Conclusion: Serum adiponectin is statistically higher in patients with normoglycemia compared to those with prediabetes and has a predictive value for distinguishing between patients with and without insulin resistance in the studied population. Serum leptin has a good predictive value for distinguishing between patients with and without MetS in the studied population.