Role of transforming growth factor-beta 1 in triple negative breast cancer patients
Role of transforming growth factor-beta 1 in triple negative breast cancer patients
复制标题
转化生长因子-β1 在三阴性乳腺癌患者中的作用
DOI：
10.1016/j.ijsu.2017.07.080
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发表时间：
2017
影响因子：
15.3
通讯作者：
Liu Jieqiong
中科院分区：
文献类型：
--
作者：
Zhang Mingxia;Wu Jiannan;Mao Kai;Deng Heran;Yang Yaping;Zhou Enxiang;Liu Jieqiong
背景我们旨在证明TGF-β1在三阴性乳腺癌（triple negative breast cancer，TNBC）中的预后价值及其与TNBC临床病理特征的相关性。免疫组化半定量检测TGF-β1的表达。采用卡方检验分析TGF-β1表达与临床病理特征的关系。单因素和多因素生存分析，以确定TGF-β1的表达对生存outcomes.ResultsOf的180名妇女在这项研究中，67（37.2%）患者表达高水平的TGF-β1的预后作用。胞浆TGF-β1高表达与肿瘤组织学分级（P< 0.001）、淋巴结状态（P <0.001）和腋窝淋巴结清扫次数（P= 0.029）相关。对数秩检验显示TGF-β1高表达与无病生存期（DFS）和总生存期（OS）降低相关（PDFS<0.001，POS = 0.045）。然而，多变量生存分析显示，高TGF-β1与不利的DFS轻微相关（风险比（HR）1.796，95%CI 0.995- 3.242，P = 0.052），而与OS无显著相关性结论TGF-β1在TNBC中的高表达与TNBC的组织学分级和淋巴结转移有关，更多的腋窝淋巴结清扫，以及降低DFS。我们对TGF-β1在TNBC中的预后作用的观察表明，在晚期肿瘤中使用基于靶向TGF-β1的治疗策略可能是合理的。
BackgroundWe aimed to demonstrate the prognostic value of TGF-β1 in triple negative breast cancer (TNBC) and its association with clinicopathological characteristics of TNBC.Materials and methodsA total of 180 women were randomly selected from non-metastatic invasive TNBC patients diagnosed at two hospitals between 2003 and 2012. Lmmunohistochemistry was performed to semi-quantify the expression of TGF-β1. Relationship between TGF-β1 expression and clinicopathological features was performed by Chi-square test. Univariate and multivariate survival analyses were performed to identify the prognostic role of TGF-β1 expression on survival outcomes.ResultsOf the 180 women included in this study, 67 (37.2%) patients expressed high level of TGF-β1. High expression of cytoplasmic TGF-β1 was correlated with higher histologic tumor grade (P< 0.001) and lymph node status (P< 0.001), and more axillary lymph node dissection (P= 0.029). High cytoplasmic TGF-β1 expression was associated with reduced disease-free survival (DFS) and overall survival (OS) by log-rank test (PDFS<0.001,POS= 0.045). However, multivariate survival analyses showed that high TGF-β1 was marginally correlated with unfavorable DFS (hazard ratio (HR) 1.796, 95% CI 0.995–3.242,P= 0.052), while it was not significantly associated with OS (HR 0.747, 95% CI 0.367–1.522,P= 0.422).ConclusionsThis multi-centered retrospective study highlights the high expression of cytoplasmic TGF-β1 in TNBC is associated with higher histologic grade and lymph node status, more axillary lymph node dissection, as well as reduced DFS. Our observation that the prognostic role of TGF-β1 in TNBC suggests potential rationale for using therapeutic strategies based on targeting TGF-β1 in advanced tumors.