Interactions between the cell cycle and embryonic patterning in Arabidopsis uncovered by a mutation in DNA polymerase ε
Interactions between the cell cycle and embryonic patterning in Arabidopsis uncovered by a mutation in DNA polymerase ε
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DOI：
10.1105/tpc.105.036889
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发表时间：
2005-12-01
期刊：
影响因子：
11.6
通讯作者：
Barton, MK
中科院分区：
文献类型：
--
作者：
Jenik, PD;Jurkuta, REJ;Barton, MK
图案的形成和形态的形成需要细胞分裂速度和方向与指定细胞命运的发育信号相协调。TILTED1基因编码拟南芥DNA聚合酶的催化亚单位，TILTED1基因的一个活性突变会导致细胞周期在整个胚胎发育过程中延长约35%，并改变根中脑垂体谱系的细胞型模式，导致根杆从其在胚柄顶部的正常位置移位。用DNA聚合酶抑制剂aphidiclin处理球状前期和球状早期，但不是后期，胚胎会导致类似的表型。这些结果揭示了细胞周期和决定植物胚胎发生期间细胞命运的过程之间的相互作用。
Pattern formation and morphogenesis require coordination of cell division rates and orientations with developmental signals that specify cell fate. A viable mutation in the TILTED1 locus, which encodes the catalytic subunit of DNA polymerase e of Arabidopsis thaliana, causes a lengthening of the cell cycle by similar to 35% throughout embryo development and alters cell type patterning of the hypophyseal lineage in the root, leading to a displacement of the root pole from its normal position on top of the suspensor. Treatment of preglobular and early globular stages, but not later stage, embryos with the DNA polymerase inhibitor aphidicolin leads to a similar phenotype. The results uncover an interaction between the cell cycle and the processes that determine cell fate during plant embryogenesis.