Bioresponsive Controlled Release Using Mesoporous Silica Nanoparticles Capped with Aptamer-Based Molecular Gate
Bioresponsive Controlled Release Using Mesoporous Silica Nanoparticles Capped with Aptamer-Based Molecular Gate
复制标题
使用带有适配体分子门的介孔二氧化硅纳米粒子进行生物响应控制释放
DOI：
10.1021/ja110094g
复制
发表时间：
2011-02-09
影响因子：
15
通讯作者：
Wang, Xiao-Ru
中科院分区：
文献类型：
--
作者：
Zhu, Chun-Ling;Lu, Chun-Hua;Wang, Xiao-Ru
本通讯描述了一种新的和一般的生物响应控制释放的介孔二氧化硅（MS）纳米粒子系统的设计基础上的适体-目标相互作用。在该系统中，MS的孔被用适体（在这种情况下为ATP适体）修饰的Au纳米颗粒覆盖。通过竞争置换反应，Au纳米颗粒在ATP分子的存在下脱帽，并释放货物。我们的研究结果表明，适体-靶相互作用可能是一个有前途的路线，为定制的控制释放纳米器件的设计，特别是由目标生物分子。由于适体已经获得了广泛的目标，包括几个癌症生物标志物，我们认为，这种基于适体的控释系统应该有一个同样广泛的应用。
This communication describes the design of a novel and general bioresponsive controlled-release mesoporous silica (MS) nanoparticles system based on aptamer- target interactions. In this system, the pores of MS were capped with Au nanoparticles modified with aptamer (ATP aptamer in this case). By a competitive displacement reaction, the Au nanoparticles were uncapped in the presence of ATP molecule, and the cargo was released. Our results demonstrated that the aptamer-target interaction may be a promising route for the design of custom-made controlled-release nanodevices specifically governed by target biomolecules. Since aptamers have been obtained for a broad range of targets, including several cancer biomarkers, we believe that this aptamer-based controlled-release system should have an equally broad spectrum of applications.